GstO1 Glutathione S transferase O1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: GstO1provided by FlyBase
Official Full Name: Glutathione S transferase O1provided by FlyBase
Primary source: FLYBASE:FBgn0035907
Locus tag: Dmel_CG6662
See related: AllianceGenome:FB:FBgn0035907
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG6662; dGstO1; Dmel\CG6662; DmGSTO1; GSTO1
Summary: Enables glutathione dehydrogenase (ascorbate) activity and glutathione transferase activity. Involved in glutathione metabolic process. Predicted to be active in cytoplasm. Is expressed in organism. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; and asthma. Orthologous to human GSTO1 (glutathione S-transferase omega 1) and GSTO2 (glutathione S-transferase omega 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (8523742..8524866, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (8516842..8517966, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

critical role in regulating sensitivity to ethanol sedation
Title: Glutathione transferase modulates acute ethanol-induced sedation in Drosophila neurones.
GstO1 inhibits H2O2-mediated activation of the mitogen-activated protein kinase (MAPK) pathway.
Title: Protective effect of Drosophila glutathione transferase omega 1 against hydrogen peroxide-induced neuronal toxicity.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables glutathione dehydrogenase (ascorbate) activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione dehydrogenase (ascorbate) activity	IDA Inferred from Direct Assay more info	PubMed
enables glutathione transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables glutathione transferase activity	IEA Inferred from Electronic Annotation more info
NOT enables pyrimidodiazepine synthase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in glutathione metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glutathione metabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info

NP_648237.1

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The following sections contain reference sequences that belong to a specific genome build. Explain