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    Rbbp5 Retinoblastoma binding protein 5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40239, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Rbbp5provided by FlyBase
    Official Full Name
    Retinoblastoma binding protein 5provided by FlyBase
    Primary source
    FLYBASE:FBgn0036973
    Locus tag
    Dmel_CG5585
    See related
    AllianceGenome:FB:FBgn0036973
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5585; Dmel\CG5585; dRbbp5; rbbp5; RbBP5; RBBP5
    Summary
    Part of MLL3/4 complex and Set1C/COMPASS complex. Is expressed in several structures, including antennal primordium; anterior endoderm; cuboidal/columnar epithelium; embryonic/larval midgut primordium; and head epidermis primordium. Orthologous to human RBBP5 (RB binding protein 5, histone lysine methyltransferase complex subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Rbbp5 in Genome Data Viewer
    Location:
    77B4-77B4; 3-47 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (20345736..20347942, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (20338836..20341042, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Serpin 77Bc Neighboring gene pseudo Neighboring gene eukaryotic translation release factor 1 Neighboring gene uncharacterized protein Neighboring gene kin17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Validating Candidate Congenital Heart Disease Genes in Drosophila. Zhu JY, et al. Bio Protoc, 2017 Jun 20. PMID 29276722, Free PMC Article
    2. Distinct roles of COMPASS subunits to Drosophila heart development. Zhu JY, et al. Biol Open, 2024 Jul 15. PMID 39417277, Free PMC Article
    3. dSet1 is the main H3K4 di- and tri-methyltransferase throughout Drosophila development. Hallson G, et al. Genetics, 2012 Jan. PMID 22048023, Free PMC Article
    4. Enhancer-associated H3K4 monomethylation by Trithorax-related, the Drosophila homolog of mammalian Mll3/Mll4. Herz HM, et al. Genes Dev, 2012 Dec 1. PMID 23166019, Free PMC Article
    5. Trithorax maintains the functional heterogeneity of neural stem cells through the transcription factor buttonhead. Komori H, et al. Elife, 2014 Oct 6. PMID 25285447, Free PMC Article

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Component Evidence Code Pubs
    part_of MLL1/2 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of MLL3/4 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Set1C/COMPASS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Set1C/COMPASS complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Set1C/COMPASS complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    retinoblastoma binding protein 5
    Names
    CG5585-PA
    Rbbp5-PA
    Retinoblastoma-binding
    protein 5

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      20345736..20347942 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140952.3 → NP_649209.1  retinoblastoma binding protein 5 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649209.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B3DMX7, Q9VPH8
      Related
      FBpp0077900
      Conserved Domains (3) summary
      COG2319
      Location:30 → 340
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:29 → 64
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:28 → 321
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VPH8.2 Q9VPH8

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