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    CG6420 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43218, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG6420provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039451
    Locus tag
    Dmel_CG6420
    See related
    AllianceGenome:FB:FBgn0039451
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG6420
    Summary
    Predicted to enable deubiquitinase activator activity. Involved in negative regulation of ubiquitin-dependent protein catabolic process and positive regulation of canonical Wnt signaling pathway. Part of peptidase complex. Is expressed in adult head and organism. Orthologous to several human genes including WDR20 (WD repeat domain 20). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG6420 in Genome Data Viewer
    Location:
    97C5-97C5; 3-91 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (26719847..26725216, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (22545569..22550938, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Yip1-interacting factor 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The USP46 deubiquitylase complex increases Wingless/Wnt signaling strength by stabilizing Arrow/LRP6. Spencer ZT, et al. Nat Commun, 2023 Oct 5. PMID 37798281, Free PMC Article
    2. Genetic Modifiers of Neurodegeneration in a Drosophila Model of Parkinson's Disease. Lavoy S, et al. Genetics, 2018 Aug. PMID 29907646, Free PMC Article
    3. Genetic Architecture of Abdominal Pigmentation in Drosophila melanogaster. Dembeck LM, et al. PLoS Genet, 2015 May. PMID 25933381, Free PMC Article
    4. In vivo profiling of the Zucchini proximal proteome in the Drosophila ovary. Nguyen TTM, et al. Development, 2023 Feb 15. PMID 36762624
    5. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables deubiquitinase activator activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of peptidase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG6420-PA
    CG6420-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      26719847..26725216 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300616.1 → NP_001287545.1  uncharacterized protein Dmel_CG6420, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287545.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8T4E0, Q9VBC4
      Conserved Domains (3) summary
      COG2319
      Location:193 → 509
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:284 → 330
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:297 → 417
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_143242.3 → NP_651499.2  uncharacterized protein Dmel_CG6420, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651499.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8T4E0, Q9VBC4
      Related
      FBpp0084418
      Conserved Domains (3) summary
      COG2319
      Location:193 → 509
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:284 → 330
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:297 → 417
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VBC4 Q9VBC4

    Gene LinkOut

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