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    CG2224 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43617, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG2224provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039773
    Locus tag
    Dmel_CG2224
    See related
    AllianceGenome:FB:FBgn0039773
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Amsh; AMSH; Dmel\CG2224; Q9VA71
    Summary
    Predicted to enable K63-linked deubiquitinase activity. Predicted to be involved in late endosome to vacuole transport via multivesicular body sorting pathway. Predicted to be active in endosome and membrane. Is expressed in adult head and presumptive embryonic/larval central nervous system. Orthologous to human STAMBP (STAM binding protein) and STAMBPL1 (STAM binding protein like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG2224 in Genome Data Viewer
    Location:
    99F5-99F5; 3-100 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (30456441..30459300, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (26282163..26285022, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Osiris 23 Neighboring gene aralar1 Neighboring gene Ceramidase Neighboring gene prolyl-4-hydroxylase-alpha EFB Neighboring gene sanpodo

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ceramidase regulates synaptic vesicle exocytosis and trafficking. Rohrbough J, et al. J Neurosci, 2004 Sep 8. PMID 15356190, Free PMC Article
    2. Deubiquitinase Usp8 regulates α-synuclein clearance and modifies its toxicity in Lewy body disease. Alexopoulou Z, et al. Proc Natl Acad Sci U S A, 2016 Aug 9. PMID 27444016, Free PMC Article
    3. The TRC8 ubiquitin ligase is sterol regulated and interacts with lipid and protein biosynthetic pathways. Lee JP, et al. Mol Cancer Res, 2010 Jan. PMID 20068067, Free PMC Article
    4. Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1. Cope GA, et al. Science, 2002 Oct 18. PMID 12183637
    5. Close head-to-head juxtaposition of genes favors their coordinate regulation in Drosophila melanogaster. Herr DR, et al. FEBS Lett, 2004 Aug 13. PMID 15304339

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables K63-linked deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables K63-linked deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal-dependent deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in late endosome to vacuole transport via multivesicular body sorting pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein K63-linked deubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG2224-PA
    CG2224-PB
    NP_001263108.1
    NP_651796.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      30456441..30459300 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001276179.1 → NP_001263108.1  uncharacterized protein Dmel_CG2224, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263108.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VA71
      Conserved Domains (2) summary
      cd08066
      Location:247 → 419
      MPN_AMSH_like; Mov34/MPN/PAD-1 family
      pfam08969
      Location:16 → 119
      USP8_dimer; USP8 dimerization domain

    2. NM_143539.3 → NP_651796.1  uncharacterized protein Dmel_CG2224, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651796.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VA71
      Related
      FBpp0085053
      Conserved Domains (2) summary
      cd08066
      Location:247 → 419
      MPN_AMSH_like; Mov34/MPN/PAD-1 family
      pfam08969
      Location:16 → 119
      USP8_dimer; USP8 dimerization domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8T8R5 Q8T8R5
    Q9VA71 Q9VA71

    Gene LinkOut

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