sau sauron [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: sauprovided by FlyBase
Official Full Name: sauronprovided by FlyBase
Primary source: FLYBASE:FBgn0267378
Locus tag: Dmel_CG7085
See related: AllianceGenome:FB:FBgn0267378
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:LD10657; BEST:LD28579; CG7085; dGOLPH3; Dmel\CG7085; GOLPH3; l(2)s5379; Rotini; rti; Rti; Sauron; Vps74
Summary: Enables phospholipid binding activity and small GTPase binding activity. Involved in several processes, including cytoskeleton-dependent cytokinesis; retrograde transport, vesicle recycling within Golgi; and spindle assembly. Located in Golgi membrane and cleavage furrow. Is expressed in several structures, including amnioserosa primordium; anterior endoderm anlage; epithelium; mesoderm; and spermatocyte. Orthologous to several human genes including GOLPH3 (golgi phosphoprotein 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 22D4-22D4; 2-5 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (2226342..2231099)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (2226342..2231099)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GOLPH3 protein controls organ growth by interacting with TOR signaling proteins in Drosophila.
Title: GOLPH3 protein controls organ growth by interacting with TOR signaling proteins in Drosophila.
A novel coordinated function of Myosin II with GOLPH3 controls centralspindlin localization during cytokinesis in Drosophila.
Title: A novel coordinated function of Myosin II with GOLPH3 controls centralspindlin localization during cytokinesis in Drosophila.
It has been demonstrated that the COG complex cooperates with Rab1 and GOLPH3 to regulate Golgi trafficking, and that overexpression of Rab1 can rescue the cytokinesis and locomotor defects associated with loss of Cog7.
Title: COG7 deficiency in Drosophila generates multifaceted developmental, behavioral and protein glycosylation phenotypes.
Study provides evidence that Rab1, by associating with GOLPH3, controls membrane trafficking and contractile ring constriction during cytokinesis.
Title: Rab1 interacts with GOLPH3 and controls Golgi structure and contractile ring constriction during cytokinesis in Drosophila melanogaster.
Because cytokinesis failures have been associated with premalignant disease and cancer, our studies suggest novel insight into molecular circuits involving the oncogene GOLPH3 in cytokinesis
Title: GOLPH3 is essential for contractile ring formation and Rab11 localization to the cleavage site during cytokinesis in Drosophila melanogaster.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables cargo adaptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidic acid binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol-3-phosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol-4-phosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-4-phosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol-4-phosphate binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-5-phosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables small GTPase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Golgi organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in Golgi organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Golgi to plasma membrane protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in Golgi vesicle budding	IBA Inferred from Biological aspect of Ancestor more info
involved_in actomyosin contractile ring assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cleavage furrow formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male meiosis cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiosis I cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiosis II cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein targeting to Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
involved_in retrograde transport, vesicle recycling within Golgi	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
involved_in spindle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spindle assembly involved in male meiosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in symbiont entry into host cell	HMP more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
is_active_in Golgi cisterna	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi cisterna	ISS Inferred from Sequence or Structural Similarity more info
located_in Golgi membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cleavage furrow	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in trans-Golgi network	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: sauron

Names: CG7085-PA; CG7085-PD; CG7085-PE; lethal (2) s5379; rotini; sau-PA; sau-PD; sau-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

2226342..2231099

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001014460.3 → NP_001014460.1 sauron, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014460.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9VQ93

Conserved Domains (1) summary

pfam05719
Location:58 → 267

GPP34; Golgi phosphoprotein 3 (GPP34)
NM_134814.5 → NP_608658.1 sauron, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_608658.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9VQ93

Related

FBpp0100138

Conserved Domains (1) summary

pfam05719
Location:58 → 267

GPP34; Golgi phosphoprotein 3 (GPP34)
NM_001032049.2 → NP_001027220.1 sauron, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001027220.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9VQ93

Conserved Domains (1) summary

pfam05719
Location:58 → 267

GPP34; Golgi phosphoprotein 3 (GPP34)