U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Ltn1 Listerin E3 ubiquitin protein ligase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40127, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Ltn1provided by FlyBase
    Official Full Name
    Listerin E3 ubiquitin protein ligase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0262517
    Locus tag
    Dmel_CG32210
    See related
    AllianceGenome:FB:FBgn0262517
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG32210; CG9268; CG9274; Dmel\CG32210; l(3)76BDr
    Summary
    Predicted to enable ribosomal large subunit binding activity; ubiquitin protein ligase activity; and zinc ion binding activity. Involved in ribosome-associated ubiquitin-dependent protein catabolic process. Predicted to be part of RQC complex. Predicted to be active in cytosol. Is expressed in adult head. Orthologous to human LTN1 (listerin E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Ltn1 in Genome Data Viewer
    Location:
    76B6-76B7; 3-45 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19544345..19552290, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19537445..19545390, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Cuticular protein 76Bd Neighboring gene uncharacterized protein Neighboring gene Dctn1-related Neighboring gene antisense RNA:CR43885 Neighboring gene uncharacterized protein Neighboring gene Reduction in Cnn dots 7 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44677

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A functional involvement of ABCE1, eukaryotic ribosome recycling factor, in nonstop mRNA decay in Drosophila melanogaster cells. Kashima I, et al. Biochimie, 2014 Nov. PMID 25128630
    2. Inefficient quality control of ribosome stalling during APP synthesis generates CAT-tailed species that precipitate hallmarks of Alzheimer's disease. Rimal S, et al. Acta Neuropathol Commun, 2021 Oct 18. PMID 34663454, Free PMC Article
    3. Mechanisms Linking Mitochondrial Dysfunction and Proteostasis Failure. Lu B, et al. Trends Cell Biol, 2020 Apr. PMID 32200806, Free PMC Article
    4. Ribosome stalling during c-myc translation presents actionable cancer cell vulnerability. Khaket TP, et al. PNAS Nexus, 2024 Aug. PMID 39161732, Free PMC Article
    5. Drosophila pipe protein activity in the ovary and the embryonic salivary gland does not require heparan sulfate glycosaminoglycans. Zhu X, et al. Development, 2005 Sep. PMID 16049108

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ribosomal large subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in rescue of stalled ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosome-associated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosome-associated ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosome-associated ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RQC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RQC complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    listerin E3 ubiquitin protein ligase 1
    Names
    CG32210-PA
    Ltn1-PA
    l(3)76BDr
    listerin

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      19544345..19552290 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168802.2 → NP_730427.1  listerin E3 ubiquitin protein ligase 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730427.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8T3L4, Q9VW09
      Related
      FBpp0074742
      Conserved Domains (1) summary
      cl17238
      Location:1724 → 1744
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VW09.2 Q9VW09

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous