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    PIG-G Phosphatidylinositol glycan anchor biosynthesis class G [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35685, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PIG-Gprovided by FlyBase
    Official Full Name
    Phosphatidylinositol glycan anchor biosynthesis class Gprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033187
    Locus tag
    Dmel_CG2144
    See related
    AllianceGenome:FB:FBgn0033187
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2144; Dmel\CG2144; PIGG
    Summary
    Predicted to enable CP2 mannose-ethanolamine phosphotransferase activity. Predicted to be involved in GPI anchor biosynthetic process. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult head and spermatozoon. Orthologous to human PIGG (phosphatidylinositol glycan anchor biosynthesis class G (EMM blood group)). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See PIG-G in Genome Data Viewer
    Location:
    43D1-43D1; 2-56 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7519280..7522541)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3406785..3410046)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Origin recognition complex subunit 1 Neighboring gene Death resistor Adh domain containing target Neighboring gene long non-coding RNA:CR44209

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Variant-to-gene mapping followed by cross-species genetic screening identifies GPI-anchor biosynthesis as a regulator of sleep. Palermo J, et al. Sci Adv, 2023 Jan 6. PMID 36608130, Free PMC Article
    2. GPI biosynthesis is essential for rhodopsin sorting at the trans-Golgi network in Drosophila photoreceptors. Satoh T, et al. Development, 2013 Jan 15. PMID 23250212
    3. Genome-wide phenotypic RNAi screen in the Drosophila wing: phenotypic description of functional classes. López-Varea A, et al. G3 (Bethesda), 2021 Dec 8. PMID 34599810, Free PMC Article
    4. mRNA-Associated Processes and Their Influence on Exon-Intron Structure in Drosophila melanogaster. Lepennetier G, et al. G3 (Bethesda), 2016 Jun 1. PMID 27172210, Free PMC Article
    5. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables CP2 mannose-ethanolamine phosphotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mannose-ethanolamine phosphotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GPI anchor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidylinositol glycan anchor biosynthesis class G
    Names
    CG2144-PA
    PIG-G-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7519280..7522541
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136448.3 → NP_610292.2  phosphatidylinositol glycan anchor biosynthesis class G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610292.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z705
      Related
      FBpp0087978
      Conserved Domains (1) summary
      cd16024
      Location:60 → 317
      GPI_EPT_2; GPI ethanolamine phosphate transferase 2; PIG-G
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z705 A1Z705
    Q8T0U3 Q8T0U3

    Gene LinkOut

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