PCB Pyruvate carboxylase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: PCBprovided by FlyBase
Official Full Name: Pyruvate carboxylaseprovided by FlyBase
Primary source: FLYBASE:FBgn0027580
Locus tag: Dmel_CG1516
See related: AllianceGenome:FB:FBgn0027580
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA; BcDNA:GH06348; CG1516; Dmel\CG1516; dPC; PC; pcb; Q0E9E2_DROME
Summary: Enables pyruvate carboxylase activity. Predicted to be involved in gluconeogenesis; oxaloacetate metabolic process; and pyruvate metabolic process. Located in mitochondrion. Is expressed in adult head; adult heart; and spermatozoon. Human ortholog(s) of this gene implicated in pyruvate carboxylase deficiency disease. Orthologous to human PC (pyruvate carboxylase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 46B4-46B4; 2-61 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (9850703..9861543, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (5738208..5749048, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables pyruvate carboxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables pyruvate carboxylase activity	IDA Inferred from Direct Assay more info	PubMed
enables pyruvate carboxylase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in gluconeogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in gluconeogenesis	IEA Inferred from Electronic Annotation more info
involved_in gluconeogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in oxaloacetate metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in pyruvate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in pyruvate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in pyruvate metabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrial matrix	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	HDA more info	PubMed

General protein information

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Preferred Names: pyruvate carboxylase

Names: CG1516-PA; CG1516-PB; CG1516-PD; CG1516-PE; CG1516-PG; CG1516-PI; CG1516-PJ; CG1516-PK; CG1516-PL; CG1516-PM; GH06348; PCB-PA; PCB-PB; PCB-PD; PCB-PE; PCB-PG; PCB-PI; PCB-PJ; PCB-PK; PCB-PL; PCB-PM; pyruvate carboxykinase

NP_001163103.1

EC 6.4.1.1

NP_610527.1

EC 6.4.1.1

NP_724837.1

EC 6.4.1.1

NP_724838.1

EC 6.4.1.1

NP_724839.1

EC 6.4.1.1

NP_724840.1

EC 6.4.1.1

NP_724841.1

EC 6.4.1.1

NP_724842.1

EC 6.4.1.1

NP_724843.1

EC 6.4.1.1

NP_724844.1

EC 6.4.1.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

9850703..9861543 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_136683.3 → NP_610527.1 pyruvate carboxylase, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_610527.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7KN97

Related

FBpp0087540

Conserved Domains (7) summary

TIGR01235
Location:41 → 1181

pyruv_carbox; pyruvate carboxylase

cd06850
Location:1114 → 1180

biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...

cd07937
Location:568 → 851

DRE_TIM_PC_TC_5S; Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain

smart00878
Location:377 → 484

Biotin_carb_C; Biotin carboxylase C-terminal domain

pfam00289
Location:39 → 147

CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain

pfam02436
Location:864 → 1062

PYC_OADA; Conserved carboxylase domain

pfam02786
Location:153 → 360

CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
NM_165709.2 → NP_724841.1 pyruvate carboxylase, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724841.1

Status: REVIEWED

UniProtKB/TrEMBL

Q0E9E2

Related

FBpp0087539

Conserved Domains (7) summary

TIGR01235
Location:41 → 1197

pyruv_carbox; pyruvate carboxylase

cd06850
Location:1130 → 1196

biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...

cd07937
Location:584 → 867

DRE_TIM_PC_TC_5S; Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain

smart00878
Location:377 → 484

Biotin_carb_C; Biotin carboxylase C-terminal domain

pfam00289
Location:39 → 147

CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain

pfam02436
Location:880 → 1078

PYC_OADA; Conserved carboxylase domain

cl17255
Location:153 → 360

ATP-grasp_4; ATP-grasp domain
NM_165707.3 → NP_724839.1 pyruvate carboxylase, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724839.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7KN97

Related

FBpp0087541

Conserved Domains (7) summary

TIGR01235
Location:41 → 1181

pyruv_carbox; pyruvate carboxylase

cd06850
Location:1114 → 1180

biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...

cd07937
Location:568 → 851

DRE_TIM_PC_TC_5S; Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain

smart00878
Location:377 → 484

Biotin_carb_C; Biotin carboxylase C-terminal domain

pfam00289
Location:39 → 147

CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain

pfam02436
Location:864 → 1062

PYC_OADA; Conserved carboxylase domain

pfam02786
Location:153 → 360

CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
NM_001169632.2 → NP_001163103.1 pyruvate carboxylase, isoform M [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163103.1

Status: REVIEWED

UniProtKB/TrEMBL

Q0E9E2

Conserved Domains (7) summary

TIGR01235
Location:41 → 1197

pyruv_carbox; pyruvate carboxylase

cd06850
Location:1130 → 1196

biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...

cd07937
Location:584 → 867

DRE_TIM_PC_TC_5S; Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain

smart00878
Location:377 → 484

Biotin_carb_C; Biotin carboxylase C-terminal domain

pfam00289
Location:39 → 147

CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain

pfam02436
Location:880 → 1078

PYC_OADA; Conserved carboxylase domain

cl17255
Location:153 → 360

ATP-grasp_4; ATP-grasp domain
NM_165705.3 → NP_724837.1 pyruvate carboxylase, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724837.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7KN97

Related

FBpp0087542

Conserved Domains (7) summary

TIGR01235
Location:41 → 1181

pyruv_carbox; pyruvate carboxylase

cd06850
Location:1114 → 1180

biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...

cd07937
Location:568 → 851

DRE_TIM_PC_TC_5S; Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain

smart00878
Location:377 → 484

Biotin_carb_C; Biotin carboxylase C-terminal domain

pfam00289
Location:39 → 147

CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain

pfam02436
Location:864 → 1062

PYC_OADA; Conserved carboxylase domain

pfam02786
Location:153 → 360

CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
NM_165710.3 → NP_724842.1 pyruvate carboxylase, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724842.1

Status: REVIEWED

UniProtKB/TrEMBL

Q0E9E2

Related

FBpp0087543

Conserved Domains (7) summary

TIGR01235
Location:41 → 1197

pyruv_carbox; pyruvate carboxylase

cd06850
Location:1130 → 1196

biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...

cd07937
Location:584 → 867

DRE_TIM_PC_TC_5S; Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain

smart00878
Location:377 → 484

Biotin_carb_C; Biotin carboxylase C-terminal domain

pfam00289
Location:39 → 147

CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain

pfam02436
Location:880 → 1078

PYC_OADA; Conserved carboxylase domain

cl17255
Location:153 → 360

ATP-grasp_4; ATP-grasp domain
NM_165706.2 → NP_724838.1 pyruvate carboxylase, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724838.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7KN97

Related

FBpp0087544

Conserved Domains (7) summary

TIGR01235
Location:41 → 1181

pyruv_carbox; pyruvate carboxylase

cd06850
Location:1114 → 1180

biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...

cd07937
Location:568 → 851

DRE_TIM_PC_TC_5S; Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain

smart00878
Location:377 → 484

Biotin_carb_C; Biotin carboxylase C-terminal domain

pfam00289
Location:39 → 147

CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain

pfam02436
Location:864 → 1062

PYC_OADA; Conserved carboxylase domain

pfam02786
Location:153 → 360

CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
NM_165711.2 → NP_724843.1 pyruvate carboxylase, isoform K [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724843.1

Status: REVIEWED

UniProtKB/TrEMBL

Q0E9E2

Related

FBpp0087545

Conserved Domains (7) summary

TIGR01235
Location:41 → 1197

pyruv_carbox; pyruvate carboxylase

cd06850
Location:1130 → 1196

biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...

cd07937
Location:584 → 867

DRE_TIM_PC_TC_5S; Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain

smart00878
Location:377 → 484

Biotin_carb_C; Biotin carboxylase C-terminal domain

pfam00289
Location:39 → 147

CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain

pfam02436
Location:880 → 1078

PYC_OADA; Conserved carboxylase domain

cl17255
Location:153 → 360

ATP-grasp_4; ATP-grasp domain
NM_165708.2 → NP_724840.1 pyruvate carboxylase, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724840.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7KN97

Related

FBpp0087547

Conserved Domains (7) summary

TIGR01235
Location:41 → 1181

pyruv_carbox; pyruvate carboxylase

cd06850
Location:1114 → 1180

biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...

cd07937
Location:568 → 851

DRE_TIM_PC_TC_5S; Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain

smart00878
Location:377 → 484

Biotin_carb_C; Biotin carboxylase C-terminal domain

pfam00289
Location:39 → 147

CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain

pfam02436
Location:864 → 1062

PYC_OADA; Conserved carboxylase domain

pfam02786
Location:153 → 360

CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
NM_165712.2 → NP_724844.1 pyruvate carboxylase, isoform L [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724844.1

Status: REVIEWED

UniProtKB/TrEMBL

Q0E9E2

Related

FBpp0087546

Conserved Domains (7) summary

TIGR01235
Location:41 → 1197

pyruv_carbox; pyruvate carboxylase

cd06850
Location:1130 → 1196

biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...

cd07937
Location:584 → 867

DRE_TIM_PC_TC_5S; Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain

smart00878
Location:377 → 484

Biotin_carb_C; Biotin carboxylase C-terminal domain

pfam00289
Location:39 → 147

CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain

pfam02436
Location:880 → 1078

PYC_OADA; Conserved carboxylase domain

cl17255
Location:153 → 360

ATP-grasp_4; ATP-grasp domain