U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    QC Glutaminyl cyclase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38663, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    QCprovided by FlyBase
    Official Full Name
    Glutaminyl cyclaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0052412
    Locus tag
    Dmel_CG32412
    See related
    AllianceGenome:FB:FBgn0052412
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10487; CG32412; Dmel\CG32412; DromeQC
    Summary
    Enables glutaminyl-peptide cyclotransferase activity. Located in extracellular region. Is expressed in adult head; embryonic hypopharynx; and organism. Orthologous to human QPCTL (glutaminyl-peptide cyclotransferase like). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    64F4-64F5; 3-15 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (5900835..5902456, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (5893935..5895556, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene DNA polymerase epsilon subunit 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Structure of glutaminyl cyclase from Drosophila melanogaster in space group I4. Kolenko P, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2013 Apr 1. PMID 23545638, Free PMC Article
    2. Phosphate ions and glutaminyl cyclases catalyze the cyclization of glutaminyl residues by facilitating synchronized proton transfers. Seifert F, et al. Bioorg Chem, 2015 Jun. PMID 25981125
    3. Crystal structures of glutaminyl cyclases (QCs) from Drosophila melanogaster reveal active site conservation between insect and mammalian QCs. Koch B, et al. Biochemistry, 2012 Sep 18. PMID 22897232
    4. Isolation and characterization of glutaminyl cyclases from Drosophila: evidence for enzyme forms with different subcellular localization. Schilling S, et al. Biochemistry, 2007 Sep 25. PMID 17722885
    5. The microevolutionary response to male-limited X-chromosome evolution in Drosophila melanogaster reflects macroevolutionary patterns. Abbott JK, et al. J Evol Biol, 2020 Jun. PMID 32176391

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Inorganic phosphate and glutaminyl cyclases catalyze N-terminal pyroglutamate formation.
      Title: Phosphate ions and glutaminyl cyclases catalyze the cyclization of glutaminyl residues by facilitating synchronized proton transfers.
    2. glutaminyl cyclase crystallized in space group I4, with unit-cell parameters a = b = 122.3, c = 72.7 A
      Title: Structure of glutaminyl cyclase from Drosophila melanogaster in space group I4.
    3. Drosophila's glutaminyl cyclases primary structures suggest different subcellular localizations. DromeQC(CG32412)appeared to be secreted due to N-term signal peptide, isoDromeQC (CG5976) contains either N-term mitochondrial targeting or secretion signal.
      Title: Isolation and characterization of glutaminyl cyclases from Drosophila: evidence for enzyme forms with different subcellular localization.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables glutaminyl-peptide cyclotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutaminyl-peptide cyclotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutaminyl-peptide cyclotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    glutaminyl cyclase
    Names
    CG32412-PA
    QC-PA
    NP_729109.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      5900835..5902456 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168145.3 → NP_729109.1  glutaminyl cyclase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729109.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VRQ9
      Related
      FBpp0076788
      Conserved Domains (1) summary
      cd03880
      Location:36 → 325
      M28_QC_like; M28 Zn-Peptidase Glutaminyl Cyclase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VRQ9.2 Q9VRQ9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous