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    CG5355 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34421, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG5355provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032242
    Locus tag
    Dmel_CG5355
    See related
    AllianceGenome:FB:FBgn0032242
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG5355
    Summary
    Enables carboxylesterase activity. Predicted to be involved in proteolysis. Predicted to be active in cytosol. Is expressed in several structures, including adult head; adult heart; central brain primordium; fat body/gonad primordium; and ganglia. Orthologous to human PREP (prolyl endopeptidase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG5355 in Genome Data Viewer
    Location:
    31E1-31E1; 2-42 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10410537..10413463, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10410537..10413463, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Ionotropic receptor 31a Neighboring gene Ribosomal protein S27A Neighboring gene Intronic Protein 259 Neighboring gene Kinesin-like protein at 31E Neighboring gene Replication factor C subunit 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional fat body proteomics and gene targeting reveal in vivo functions of Drosophila melanogaster α-Esterase-7. Birner-Gruenberger R, et al. Insect Biochem Mol Biol, 2012 Mar. PMID 22198472
    2. Targets of microRNA regulation in the Drosophila oocyte proteome. Nakahara K, et al. Proc Natl Acad Sci U S A, 2005 Aug 23. PMID 16099838, Free PMC Article
    3. Proteomic profiling in Drosophila reveals potential Dube3a regulation of the actin cytoskeleton and neuronal homeostasis. Jensen L, et al. PLoS One, 2013. PMID 23626758, Free PMC Article
    4. Functional variants identify sex-specific genes and pathways in Alzheimer's Disease. Bourquard T, et al. Nat Commun, 2023 May 13. PMID 37179358, Free PMC Article
    5. High-Throughput Functional Analysis Distinguishes Pathogenic, Nonpathogenic, and Compensatory Transcriptional Changes in Neurodegeneration. Al-Ramahi I, et al. Cell Syst, 2018 Jul 25. PMID 29936182, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables carboxylesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oligopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine hydrolase activity HDA PubMed 
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG5355-PA
    NP_609397.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10410537..10413463 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135553.4 → NP_609397.2  uncharacterized protein Dmel_CG5355 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609397.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q961N7, Q9VKW5
      Related
      FBpp0079637
      Conserved Domains (3) summary
      COG0657
      Location:442 → 750
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam00326
      Location:541 → 752
      Peptidase_S9; Prolyl oligopeptidase family
      pfam02897
      Location:51 → 467
      Peptidase_S9_N; Prolyl oligopeptidase, N-terminal beta-propeller domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q961N7 Q961N7
    Q9VKW5 Q9VKW5

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