U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    alrm astrocytic leucine-rich repeat molecule [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43074, updated on 17-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    alrmprovided by FlyBase
    Official Full Name
    astrocytic leucine-rich repeat moleculeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039332
    Locus tag
    Dmel_CG11910
    See related
    AllianceGenome:FB:FBgn0039332
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Alrm; CG11910; CT37074; Dmel\CG11910
    Summary
    Is expressed in adult head; adult mushroom body; glial cell; larval ventral nerve cord; and synaptic neuropil domain. Orthologous to human NRROS (negative regulator of reactive oxygen species) and TSKU (tsukushi, small leucine rich proteoglycan). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See alrm in Genome Data Viewer
    Location:
    96D2-96D3; 3-87 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25381065..25382781, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21206785..21208503, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene rha Neighboring gene target of brain insulin Neighboring gene Furin 1 Neighboring gene NADH dehydrogenase (ubiquinone) 49 kDa subunit-like Neighboring gene uncharacterized protein Neighboring gene Mucin 96D

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Astrocyte-like glial cells physiologically regulate olfactory processing through the modification of ORN-PN synaptic strength in Drosophila. Liu H, et al. Eur J Neurosci, 2014 Sep. PMID 24964821
    2. The astrocyte network in the ventral nerve cord neuropil of the Drosophila third-instar larva. Hernandez E, et al. J Comp Neurol, 2020 Jul. PMID 31909826
    3. Astrocytic expression of the chaperone DNAJB6 results in non-cell autonomous protection in Huntington's disease. Bason M, et al. Neurobiol Dis, 2019 Apr. PMID 30408590
    4. Monitoring cell-cell contacts in vivo in transgenic animals. Huang TH, et al. Development, 2016 Nov 1. PMID 27660327, Free PMC Article
    5. Comparative analysis of the brain transcriptome in a hyper-aggressive fruit fly, Drosophila prolongata. Kudo A, et al. Insect Biochem Mol Biol, 2017 Mar. PMID 28115271

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    astrocytic leucine-rich repeat molecule
    Names
    CG11910-PA
    alrm-PA

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      25381065..25382781 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143136.4 → NP_651393.1  astrocytic leucine-rich repeat molecule [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651393.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1NZE0, Q9VBR3
      Related
      FBpp0084220
      Conserved Domains (3) summary
      cd00116
      Location:84 → 354
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:91 → 114
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:138 → 197
      LRR_8; Leucine rich repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VBR3 Q9VBR3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous