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    Mlh1 Mlh1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35796, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mlh1provided by FlyBase
    Official Full Name
    Mlh1provided by FlyBase
    Primary source
    FLYBASE:FBgn0011659
    Locus tag
    Dmel_CG11482
    See related
    AllianceGenome:FB:FBgn0011659
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11482; Dmel\CG11482; dmlh-1; dmlh1; mlh1; MLH1
    Summary
    Predicted to enable ATP hydrolysis activity. Predicted to be involved in mismatch repair. Predicted to be part of MutLalpha complex. Human ortholog(s) of this gene implicated in Lynch syndrome (multiple); gastrointestinal system cancer (multiple); lung cancer; mismatch repair cancer syndrome; and sporadic breast cancer. Orthologous to human MLH1 (mutL homolog 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Mlh1 in Genome Data Viewer
    Location:
    44B8-44B8; 2-58 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8170274..8172401)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4057779..4059906)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Rs1 Neighboring gene gasz Neighboring gene uncharacterized protein Neighboring gene LDL receptor protein 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Whence meiosis? Villeneuve AM, et al. Cell, 2001 Sep 21. PMID 11572770
    2. DNA mismatch repair and mutation avoidance pathways. Marti TM, et al. J Cell Physiol, 2002 Apr. PMID 11920679
    3. Mlh1 is required for female fertility in Drosophila melanogaster: An outcome of effects on meiotic crossing over, ovarian follicles and egg activation. Vimal D, et al. Eur J Cell Biol, 2018 Mar. PMID 29290392
    4. Atrazine or bisphenol A mediated negative modulation of mismatch repair gene, mlh1 leads to defective oogenesis and reduced female fertility in Drosophila melanogaster. Vimal D, et al. Chemosphere, 2019 Jun. PMID 30877919
    5. Sustained inactivation of the Polycomb PRC1 complex induces DNA repair defects and genomic instability in epigenetic tumors. Rawal CC, et al. Histochem Cell Biol, 2024 Jul. PMID 38888809, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Reduction of the Mlh1 protein level leads to defective oocytes that fail to complete embryogenesis after fertilization thereby reducing female fertility.
      Title: Mlh1 is required for female fertility in Drosophila melanogaster: An outcome of effects on meiotic crossing over, ovarian follicles and egg activation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent DNA damage sensor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mismatched DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mismatch repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mismatch repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of MutLalpha complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mismatch repair complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mlh1
    Names
    CG11482-PA
    CG11482-PB
    Mlh1-PA
    Mlh1-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      8170274..8172401
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273870.1 → NP_001260799.1  Mlh1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260799.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KEM3, O61917
      Conserved Domains (4) summary
      cd00075
      Location:33 → 115
      HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins
      cd03483
      Location:213 → 336
      MutL_Trans_MLH1; MutL_Trans_MLH1: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH1 (MutL homologue 1). This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to ...
      TIGR00585
      Location:8 → 316
      mutl; DNA mismatch repair protein MutL
      pfam16413
      Location:423 → 663
      Mlh1_C; DNA mismatch repair protein Mlh1 C-terminus

    2. NM_057674.3 → NP_477022.1  Mlh1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477022.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z7C1, O61917
      Related
      FBpp0087867
      Conserved Domains (4) summary
      cd00075
      Location:33 → 115
      HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins
      cd03483
      Location:213 → 337
      MutL_Trans_MLH1; MutL_Trans_MLH1: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH1 (MutL homologue 1). This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to ...
      TIGR00585
      Location:8 → 317
      mutl; DNA mismatch repair protein MutL
      pfam16413
      Location:424 → 664
      Mlh1_C; DNA mismatch repair protein Mlh1 C-terminus
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KEM3 A0A0B4KEM3
    A1Z7C1 A1Z7C1
    O61917 O61917
    Q8T0N1 Q8T0N1

    Gene LinkOut

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