Rab35 Rab35 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Rab35provided by FlyBase
Official Full Name: Rab35provided by FlyBase
Primary source: FLYBASE:FBgn0031090
Locus tag: Dmel_CG9575
See related: AllianceGenome:FB:FBgn0031090
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG9575; Dmel\CG9575; DmRab35; dRab35; DRab35; Q95RH7; rab35; Rab35 CES
Summary: Predicted to enable GTP binding activity and GTPase activity. Involved in several processes, including apical protein localization; endosomal transport; and regulation of embryonic development. Located in several cellular components, including anterior cell cortex; cytoplasmic side of apical plasma membrane; and endosome to plasma membrane transport vesicle. Is active in neuromuscular junction. Is expressed in several structures, including adult ensheathing glial cell; brain; imaginal disc; mushroom body; and synaptic neuropil domain. Orthologous to human RAB35 (RAB35, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 19B3-19B3; 1-64 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (20155766..20159872, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (20049799..20053905, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Stratum is required for both apical and basolateral transport through stable expression of Rab10 and Rab35 in Drosophila photoreceptors.
Title: Stratum is required for both apical and basolateral transport through stable expression of Rab10 and Rab35 in Drosophila photoreceptors.
Rab35 is an essential component of the contraction of epithelial surfaces, which functions as a membrane ratchet to ensure unidirectional movement of intercalating cells.
Title: Planar polarized Rab35 functions as an oscillatory ratchet during cell intercalation in the Drosophila epithelium.
Growth of seamless tubes is polarized along the proximodistal axis by Rab35 and its apical membrane-localized GAP, Whacked.
Title: Whacked and Rab35 polarize dynein-motor-complex-dependent seamless tube growth.
Recruitment of Cdc42 and Rac1 to the sites of filopodium and lamellipodium formation is Rab35 dependent and occurs by way of microtubule tracks.
Title: Rab35 mediates transport of Cdc42 and Rac1 to the plasma membrane during phagocytosis.
study found that Rab35 regulates the assembly of actin filaments during bristle development; effect was mediated by the actin-bundling protein fascin, which directly associated with active Rab35
Title: Rab35 controls actin bundling by recruiting fascin as an effector protein.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in Rab protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in Rab protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in apical protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytoskeletal rearrangement involved in phagocytosis, engulfment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytic recycling	IBA Inferred from Biological aspect of Ancestor more info
involved_in endosome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endosome to plasma membrane protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in exosomal secretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of liquid clearance, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lumen formation, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in plasma membrane to endosome transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in polarity specification of proximal/distal axis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apical constriction involved in ventral furrow formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of establishment of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of filopodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of embryonic cell shape	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in symbiont entry into host cell	HMP more info	PubMed
involved_in synaptic vesicle endosomal processing	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic vesicle endosomal processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle-mediated transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in vesicle-mediated transport in synapse	IDA Inferred from Direct Assay more info	PubMed
involved_in vesicle-mediated transport in synapse	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in anterior cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic side of apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome to plasma membrane transport vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in filopodium	IDA Inferred from Direct Assay more info	PubMed
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
located_in neuronal cell body	HDA more info	PubMed
located_in plasma membrane	HDA more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in posterior cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	HDA more info	PubMed
located_in vesicle	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: Rab35

Names: CG9575-PA; CG9575-PB; CG9575-PC; CG9575-PD; Rab GTPase; Rab35-PA; Rab35-PB; Rab35-PC; Rab35-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

20155766..20159872 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001272810.1 → NP_001259739.1 Rab35, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259739.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9W5X0

Conserved Domains (1) summary

cd04110
Location:3 → 201

Rab35; Rab GTPase family 35 (Rab35)
NM_134529.4 → NP_608373.1 Rab35, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_608373.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9W5X0

Related

FBpp0070027

Conserved Domains (1) summary

cd04110
Location:3 → 201

Rab35; Rab GTPase family 35 (Rab35)
NM_001201749.2 → NP_001188678.1 Rab35, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001188678.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9W5X0

Conserved Domains (1) summary

cd04110
Location:3 → 201

Rab35; Rab GTPase family 35 (Rab35)
NM_001272809.1 → NP_001259738.1 Rab35, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259738.1

Status: REVIEWED

UniProtKB/TrEMBL

F0JAF7

Conserved Domains (2) summary

smart00175
Location:4 → 159

RAB; Rab subfamily of small GTPases

cl21455
Location:8 → 190

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases