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    Gdh Glutamate dehydrogenase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42832, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Gdhprovided by FlyBase
    Official Full Name
    Glutamate dehydrogenaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0001098
    Locus tag
    Dmel_CG5320
    See related
    AllianceGenome:FB:FBgn0001098
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5320; DHE3; Dmel\CG5320; gdh; GDH; GLU-D; Glud; GLUD; GLUD pre-mRNA
    Summary
    Enables glutamate dehydrogenase (NAD+) activity; glutamate dehydrogenase (NADP+) activity; and identical protein binding activity. Involved in NADH oxidation and glutamate metabolic process. Located in mitochondrion. Is active in mitochondrial matrix. Is expressed in several structures, including epithelium; gut section; imaginal disc; mesoderm; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 6; hyperinsulinism; and hypoglycemia. Orthologous to several human genes including GLUD1 (glutamate dehydrogenase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Gdh in Genome Data Viewer
    Location:
    95C13-95D1; 3-81 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (23935958..23943101, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19761680..19768823, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Ribosomal protein S19b Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Glutamyl-prolyl-tRNA synthetase Neighboring gene antisense RNA:CR46092

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evaluation of sub-cellular distribution of glutamate dehydrogenase (GDH) in Drosophila melanogaster larvae. Tiwari AK, et al. Acta Histochem, 2014 Mar. PMID 24139688
    2. The glutamate dehydrogenase GENE of Drosophila melanogaster: molecular analysis and expression. Papadopoulou D, et al. J Neurogenet, 2000 Sep. PMID 10992165
    3. The gene coding for glutamate dehydrogenase in Drosophila melanogaster. Papadopoulou D, et al. Biochem Genet, 1990 Aug. PMID 1702620
    4. Purification and genetic control of NAD-dependent glutamate dehydrogenase from Drosophila melanogaster. Caggese C, et al. Biochem Genet, 1982 Jun. PMID 6810872
    5. Glutamate dehydrogenase of Drosophila larvae. Bond PA, et al. J Insect Physiol, 1968 Mar. PMID 4384995

    See all (108) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables glutamate dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutamate dehydrogenase (NAD+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutamate dehydrogenase (NADP+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in NADH oxidation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glutamate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutamate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT involved_in sperm storage TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    is_active_in mitochondrial matrix IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glutamate dehydrogenase
    Names
    CG5320-PA
    CG5320-PB
    CG5320-PD
    CG5320-PF
    Gdh-PA
    Gdh-PB
    Gdh-PD
    Gdh-PF
    NAD-dependent glutamate dehydrogenase
    glutamate dehydrogenase (mitochondrial)
    NP_524470.4
    NP_732922.1
    NP_996273.2
    NP_996274.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      23935958..23943101 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206551.3 → NP_996274.1  glutamate dehydrogenase, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996274.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P54385
      Conserved Domains (3) summary
      cd01076
      Location:254 → 539
      NAD_bind_1_Glu_DH; NAD(P) binding domain of glutamate dehydrogenase, subgroup 1
      COG0334
      Location:98 → 547
      GdhA; Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]
      pfam02812
      Location:104 → 233
      ELFV_dehydrog_N; Glu/Leu/Phe/Val dehydrogenase, dimerization domain

    2. NM_079746.6 → NP_524470.4  glutamate dehydrogenase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524470.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P54385, P91624, Q8IH05, Q9VCF7
      Related
      FBpp0088988
      Conserved Domains (3) summary
      cd01076
      Location:254 → 552
      NAD_bind_1_Glu_DH; NAD(P) binding domain of glutamate dehydrogenase, subgroup 1
      COG0334
      Location:98 → 560
      GdhA; Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]
      pfam02812
      Location:104 → 233
      ELFV_dehydrog_N; Glu/Leu/Phe/Val dehydrogenase, dimerization domain

    3. NM_206550.2 → NP_996273.2  glutamate dehydrogenase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996273.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0C4DHE7
      Conserved Domains (3) summary
      cd01076
      Location:96 → 381
      NAD_bind_1_Glu_DH; NAD(P) binding domain of glutamate dehydrogenase, subgroup 1
      pfam00208
      Location:96 → 388
      ELFV_dehydrog; Glutamate/Leucine/Phenylalanine/Valine dehydrogenase
      pfam02812
      Location:1 → 75
      ELFV_dehydrog_N; Glu/Leu/Phe/Val dehydrogenase, dimerization domain

    4. NM_170101.3 → NP_732922.1  glutamate dehydrogenase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732922.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IMY1
      Related
      FBpp0088496
      Conserved Domains (3) summary
      cd01076
      Location:96 → 394
      NAD_bind_1_Glu_DH; NAD(P) binding domain of glutamate dehydrogenase, subgroup 1
      pfam00208
      Location:96 → 401
      ELFV_dehydrog; Glutamate/Leucine/Phenylalanine/Valine dehydrogenase
      pfam02812
      Location:1 → 75
      ELFV_dehydrog_N; Glu/Leu/Phe/Val dehydrogenase, dimerization domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0C4DHE7 A0A0C4DHE7
    P54385.2 P54385
    Q8IMY1 Q8IMY1

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