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    Acat1 Acetyl-CoA acetyltransferase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31695, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Acat1provided by FlyBase
    Official Full Name
    Acetyl-CoA acetyltransferase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0029969
    Locus tag
    Dmel_CG10932
    See related
    AllianceGenome:FB:FBgn0029969
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    154229_at; ACAT1; CG10932; Dmel\CG10932
    Summary
    Predicted to enable acetyl-CoA C-acetyltransferase activity. Predicted to be involved in acetyl-CoA biosynthetic process. Located in mitochondrion. Is expressed in adult head; adult heart; embryonic/larval midgut; and organism. Human ortholog(s) of this gene implicated in beta-ketothiolase deficiency and carbohydrate metabolic disorder. Orthologous to human ACAT1 (acetyl-CoA acetyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Acat1 in Genome Data Viewer
    Location:
    7C1-7C1; 1-21 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (7887130..7888785, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (7781163..7782818, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Ionotropic receptor 7f Neighboring gene Ionotropic receptor 7g Neighboring gene Nek2 Neighboring gene NADH dehydrogenase (ubiquinone) MNLL subunit Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Glia fuel neurons with locally synthesized ketone bodies to sustain memory under starvation. Silva B, et al. Nat Metab, 2022 Feb. PMID 35177854, Free PMC Article
    2. Glycolytically impaired Drosophila glial cells fuel neural metabolism via β-oxidation. McMullen E, et al. Nat Commun, 2023 May 24. PMID 37225684, Free PMC Article
    3. Glial metabolism versatility regulates mushroom body-driven behavioral output in Drosophila. Basu R, et al. Learn Mem, 2024 May. PMID 38862167, Free PMC Article
    4. Population-scale long-read sequencing uncovers transposable elements associated with gene expression variation and adaptive signatures in Drosophila. Rech GE, et al. Nat Commun, 2022 Apr 12. PMID 35413957, Free PMC Article
    5. Dietary cysteine drives body fat loss via FMRFamide signaling in Drosophila and mouse. Song T, et al. Cell Res, 2023 Jun. PMID 37055592, Free PMC Article

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables acetyl-CoA C-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acetyl-CoA C-acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in acetyl-CoA biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in peroxisome ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Acetyl-CoA acetyltransferase 1
    Names
    Acat1-PA
    Acat1-PB
    CG10932-PA
    CG10932-PB
    NP_001284987.1
    NP_572414.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      7887130..7888785 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298058.1 → NP_001284987.1  Acetyl-CoA acetyltransferase 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284987.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W3N9
      Conserved Domains (2) summary
      PLN02644
      Location:24 → 410
      PLN02644; acetyl-CoA C-acetyltransferase
      cd00751
      Location:26 → 409
      thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...

    2. NM_132186.2 → NP_572414.1  Acetyl-CoA acetyltransferase 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572414.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W3N9
      Related
      FBpp0071095
      Conserved Domains (2) summary
      PLN02644
      Location:24 → 410
      PLN02644; acetyl-CoA C-acetyltransferase
      cd00751
      Location:26 → 409
      thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W3N9 Q9W3N9

    Gene LinkOut

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