U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Cdc6 Cell division cycle 6 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38989, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Cdc6provided by FlyBase
    Official Full Name
    Cell division cycle 6provided by FlyBase
    Primary source
    FLYBASE:FBgn0035918
    Locus tag
    Dmel_CG5971
    See related
    AllianceGenome:FB:FBgn0035918
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cdc6; CDC6; CG5971; DmCdc6; Dmel\CG5971
    Summary
    Predicted to enable DNA replication origin binding activity. Predicted to be involved in DNA replication initiation and mitotic DNA replication checkpoint signaling. Located in nucleus. Is expressed in several structures, including antennal primordium; central brain primordium; embryonic/larval midgut; embryonic/larval midgut primordium; and head epidermis primordium. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 5. Orthologous to human CDC6 (cell division cycle 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Cdc6 in Genome Data Viewer
    Location:
    66D9-66D9; 3-26 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8631509..8634069, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8624609..8627169, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Sperm-Leucylaminopeptidase 1 Neighboring gene Sperm-Leucylaminopeptidase 2 Neighboring gene GTPase activating protein, SECIS-dependent read-through Neighboring gene Z band alternatively spliced PDZ-motif protein 66 Neighboring gene Cuticular protein 66D Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Juvenile Hormone Activates the Transcription of Cell-division-cycle 6 (Cdc6) for Polyploidy-dependent Insect Vitellogenesis and Oogenesis. Wu Z, et al. J Biol Chem, 2016 Mar 4. PMID 26728459, Free PMC Article
    2. Molecular evolution of Drosophila Cdc6, an essential DNA replication-licensing gene, suggests an adaptive choice of replication origins. Wiggins BL, et al. Fly (Austin), 2007 May-Jun. PMID 18618020, Free PMC Article
    3. Differential condensation of sister chromatids acts with Cdc6 to ensure asynchronous S-phase entry in Drosophila male germline stem cell lineage. Ranjan R, et al. Dev Cell, 2022 May 9. PMID 35483360, Free PMC Article
    4. The Drosophila Cdc6/18 protein has functions in both early and late S phase in S2 cells. Crevel G, et al. J Cell Sci, 2005 Jun 1. PMID 15923658
    5. Study of DNA replication in Drosophila using cell free in vitro system. Svitin A, et al. Cell Cycle, 2010 Feb 15. PMID 20139730, Free PMC Article

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural mechanism for replication origin binding and remodeling by a metazoan origin recognition complex and its co-loader Cdc6.
      Title: Structural mechanism for replication origin binding and remodeling by a metazoan origin recognition complex and its co-loader Cdc6.
    2. Cdc6 transcription is directly regulated by the juvenile hormone-receptor complex. Knockdown of Cdc6 inhibits polyploidization of fat body and follicle cells.
      Title: Juvenile Hormone Activates the Transcription of Cell-division-cycle 6 (Cdc6) for Polyploidy-dependent Insect Vitellogenesis and Oogenesis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA replication origin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic DNA replication checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    cell division cycle 6
    Names
    CG5971-PA
    Cdc6-PA

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      8631509..8634069 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139990.3 → NP_648247.1  cell division cycle 6 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648247.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q06K02, Q9VSM9
      Related
      FBpp0076371
      Conserved Domains (3) summary
      smart01074
      Location:564 → 644
      Cdc6_C; CDC6, C terminal
      TIGR02928
      Location:266 → 623
      TIGR02928; orc1/cdc6 family replication initiation protein
      pfam13401
      Location:288 → 407
      AAA_22; AAA domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VSM9 Q9VSM9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.