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    UbcE2M NEDD8-conjugating enzyme UbcE2M [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38916, updated on 9-Dec-2024

    Summary

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    Official Symbol
    UbcE2Mprovided by FlyBase
    Official Full Name
    NEDD8-conjugating enzyme UbcE2Mprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035853
    Locus tag
    Dmel_CG7375
    See related
    AllianceGenome:FB:FBgn0035853
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.309; CG7375; Dmel\CG7375; dUbc12; Ubc12; UBC12; ubcD12; UbcD12
    Summary
    Enables NEDD8 conjugating enzyme activity. Involved in negative regulation of smoothened signaling pathway; positive regulation of peptidoglycan recognition protein signaling pathway; and protein neddylation. Predicted to be active in cytosol and nucleus. Is expressed in organism and wing disc. Orthologous to human UBE2M (ubiquitin conjugating enzyme E2 M). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See UbcE2M in Genome Data Viewer
    Location:
    66B12-66B12; 3-22 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8195847..8197987, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8188947..8191087, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Autophagy-related 18a Neighboring gene Mediator complex subunit 24 Neighboring gene uncharacterized protein Neighboring gene Deoxyhypusine synthase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Protein neddylation: beyond cullin-RING ligases. Enchev RI, et al. Nat Rev Mol Cell Biol, 2015 Jan. PMID 25531226, Free PMC Article
    2. N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity. Varland S, et al. Nat Commun, 2023 Oct 27. PMID 37891180, Free PMC Article
    3. Systematic in vivo RNAi analysis identifies IAPs as NEDD8-E3 ligases. Broemer M, et al. Mol Cell, 2010 Dec 10. PMID 21145488
    4. Strabismus promotes recruitment and degradation of farnesylated prickle in Drosophila melanogaster planar polarity specification. Strutt H, et al. PLoS Genet, 2013. PMID 23874239, Free PMC Article
    5. A Cul-3-BTB ubiquitylation pathway regulates junctional levels and asymmetry of core planar polarity proteins. Strutt H, et al. Development, 2013 Apr. PMID 23487316, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that two novel genes dUba3 (CG13343) and dUbc12 ( CG7375) played a critical role in Hh signal transduction.
      Title: In vivo RNAi screen reveals neddylation genes as novel regulators of Hedgehog signaling.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables NEDD8 conjugating enzyme activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables NEDD8 transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NEDD8 transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of peptidoglycan recognition protein signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein modification process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein neddylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein neddylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein neddylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    NEDD8-conjugating enzyme UbcE2M
    Names
    CG7375-PA
    CG7375-PB
    CG7375-PC
    UbcE2M-PA
    UbcE2M-PB
    UbcE2M-PC
    ubiquitin conjugating enzyme 12
    ubiquitin conjugating enzyme E2M
    NP_001261567.1
    NP_001261568.1
    NP_648187.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      8195847..8197987 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274639.1 → NP_001261568.1  NEDD8-conjugating enzyme UbcE2M, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261568.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VSF3
      UniProtKB/TrEMBL
      M9PBW0
      Conserved Domains (1) summary
      pfam00179
      Location:30 → 165
      UQ_con; Ubiquitin-conjugating enzyme

    2. NM_139930.2 → NP_648187.1  NEDD8-conjugating enzyme UbcE2M, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648187.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VSF3
      UniProtKB/TrEMBL
      M9PBW0
      Related
      FBpp0076445
      Conserved Domains (1) summary
      pfam00179
      Location:30 → 165
      UQ_con; Ubiquitin-conjugating enzyme

    3. NM_001274638.1 → NP_001261567.1  NEDD8-conjugating enzyme UbcE2M, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261567.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VSF3
      UniProtKB/TrEMBL
      M9PBW0
      Conserved Domains (1) summary
      pfam00179
      Location:30 → 165
      UQ_con; Ubiquitin-conjugating enzyme
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PBW0 M9PBW0
    Q9VSF3.1 Q9VSF3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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