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    GAB1 GPI-anchor transamidase subunit GAB1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851181, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GAB1
    Official Full Name
    GPI-anchor transamidase subunit GAB1
    Primary source
    SGD:S000004451
    Locus tag
    YLR459W
    See related
    AllianceGenome:SGD:S000004451; FungiDB:YLR459W; VEuPathDB:YLR459W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CDC91
    Summary
    Involved in attachment of GPI anchor to protein. Located in endoplasmic reticulum. Part of GPI-anchor transamidase complex. Orthologous to human PIGU (phosphatidylinositol glycan anchor biosynthesis class U). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See GAB1 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (1057334..1058518)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene pyridoxal 5'-phosphate synthase Neighboring gene Nbp1p Neighboring gene uncharacterized protein Neighboring gene seripauperin PAU4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Deficiencies in the endoplasmic reticulum (ER)-membrane protein Gab1p perturb transfer of glycosylphosphatidylinositol to proteins and cause perinuclear ER-associated actin bar formation. Grimme SJ, et al. Mol Biol Cell, 2004 Jun. PMID 15075373, Free PMC Article
    2. Disulfide Bond Formation and N-Glycosylation Modulate Protein-Protein Interactions in GPI-Transamidase (GPIT). Yi L, et al. Sci Rep, 2017 Apr 4. PMID 28374821, Free PMC Article
    3. Human PIG-U and yeast Cdc91p are the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins. Hong Y, et al. Mol Biol Cell, 2003 May. PMID 12802054, Free PMC Article
    4. A Rab escort protein integrates the secretion system with TOR signaling and ribosome biogenesis. Singh J, et al. Genes Dev, 2009 Aug 15. PMID 19684114, Free PMC Article
    5. The role of the Parkinson's disease gene PARK9 in essential cellular pathways and the manganese homeostasis network in yeast. Chesi A, et al. PLoS One, 2012. PMID 22457822, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. depletion of Gab1p or Gpi8p, but not Gpi17p, Gpi16p, or Gaa1p causes accumulation of cofilin-decorated actin bars that are closely associated with the perinuclear endoplasmic reticulum
      Title: Deficiencies in the endoplasmic reticulum (ER)-membrane protein Gab1p perturb transfer of glycosylphosphatidylinositol to proteins and cause perinuclear ER-associated actin bar formation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in attachment of GPI anchor to protein IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in attachment of GPI anchor to protein IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in attachment of GPI anchor to protein IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of GPI-anchor transamidase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of GPI-anchor transamidase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of GPI-anchor transamidase complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of GPI-anchor transamidase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    GPI-anchor transamidase subunit GAB1
    NP_013564.1
    • Subunit of the glycosylphosphatidylinositol transamidase complex; involved in attachment of glycosylphosphatidylinositol (GPI) anchors to proteins; may have a role in recognition of the attachment signal or the lipid portion of GPI; ortholog of human PIGU; partially complements a class U CHO cell line with a mutation in the PIGU ortholog

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      1057334..1058518
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182347.1 → NP_013564.1  TPA: GPI-anchor transamidase subunit GAB1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013564.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZ92, P41733
      UniProtKB/TrEMBL
      A7A1X9, B3RHW6, B5VNZ8, C7GUD3, C8ZE65, G2WJR9, N1P0B4
      Conserved Domains (1) summary
      pfam06728
      Location:10 → 360
      PIG-U; GPI transamidase subunit PIG-U
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P41733.1

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