U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    APT1 adenine phosphoribosyltransferase APT1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854986, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    APT1
    Official Full Name
    adenine phosphoribosyltransferase APT1
    Primary source
    SGD:S000004484
    Locus tag
    YML022W
    See related
    AllianceGenome:SGD:S000004484; FungiDB:YML022W; VEuPathDB:YML022W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables adenine phosphoribosyltransferase activity. Involved in adenine salvage. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in adenine phosphoribosyltransferase deficiency. Orthologous to human APRT (adenine phosphoribosyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See APT1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (228937..229500)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene ribosomal 40S subunit protein S17A Neighboring gene Smc5-Smc6 complex subunit NSE5 Neighboring gene uracil-DNA glycosylase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Purification and characterization of adenine phosphoribosyltransferase from Saccharomyces cerevisiae. Alfonzo JD, et al. Biochim Biophys Acta, 1997 Sep 5. PMID 9357956
    2. Cloning and characterization of the adenine phosphoribosyltransferase-encoding gene (APT1) from Saccharomyces cerevisiae. Alfonzo JD, et al. Gene, 1995 Aug 8. PMID 7642142
    3. Cloning, purification, crystallization and preliminary X-ray diffraction crystallographic study of acyl-protein thioesterase 1 from Saccharomyces cerevisiae. Yuan Y, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2012 Jul 1. PMID 22750862, Free PMC Article
    4. Mutants of Saccharomyces cerevisiae deficient in adenine phosphoribosyltransferase. Sahota A, et al. Mutat Res, 1987 Sep. PMID 3306356
    5. Adenine deaminase and adenine utilization in Saccharomyces cerevisiae. Deeley MC. J Bacteriol, 1992 May. PMID 1577682, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The binding of the APT1 domains to phosphoinositides is regulated by metal ions in vitro.
      Title: The binding of the APT1 domains to phosphoinositides is regulated by metal ions in vitro.
    2. crystals of Apt1 diffracted to 2.40 A resolution and belonged to space group P4(2)2(1)2, with unit-cell parameters a = b = 146.43, c = 93.29 A
      Title: Cloning, purification, crystallization and preliminary X-ray diffraction crystallographic study of acyl-protein thioesterase 1 from Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables AMP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenine phosphoribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenine phosphoribosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables adenine phosphoribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in AMP salvage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in AMP salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenine salvage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenine salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenine salvage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in purine ribonucleoside salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    adenine phosphoribosyltransferase APT1
    NP_013690.1
    • Adenine phosphoribosyltransferase; catalyzes the formation of AMP from adenine and 5-phosphoribosylpyrophosphate; involved in the salvage pathway of purine nucleotide biosynthesis; APT1 has a paralog, APT2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      228937..229500
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182380.1 → NP_013690.1  TPA: adenine phosphoribosyltransferase APT1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013690.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZF2, P49435, Q6Q5A3
      UniProtKB/TrEMBL
      A6ZM40, B3LLN0, B5VPA4, C7GLE0, C8ZEI2, G2WK30, N1P593
      Conserved Domains (1) summary
      TIGR01090
      Location:10 → 180
      apt; adenine phosphoribosyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49435.3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous