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    END3 End3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855640, updated on 9-Dec-2024

    Summary

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    Official Symbol
    END3
    Official Full Name
    End3p
    Primary source
    SGD:S000005028
    Locus tag
    YNL084C
    See related
    AllianceGenome:SGD:S000005028; FungiDB:YNL084C; VEuPathDB:YNL084C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables protein-macromolecule adaptor activity. Involved in ascospore wall assembly and endocytosis. Acts upstream of or within reticulophagy. Located in cell periphery and mating projection tip. Part of actin cytoskeleton-regulatory complex. Orthologous to human EPS15 (epidermal growth factor receptor pathway substrate 15) and EPS15L1 (epidermal growth factor receptor pathway substrate 15 like 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See END3 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (470053..471102, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Snn1p Neighboring gene Mkt1p Neighboring gene Ca(2+)-binding ATP:ADP antiporter SAL1 Neighboring gene ATP-binding mismatch repair protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The END3 gene encodes a protein that is required for the internalization step of endocytosis and for actin cytoskeleton organization in yeast. Bénédetti H, et al. Mol Biol Cell, 1994 Sep. PMID 7841519, Free PMC Article
    2. A novel toxicity mechanism of CdSe nanoparticles to Saccharomyces cerevisiae: enhancement of vacuolar membrane permeabilization (VMP). Sun M, et al. Chem Biol Interact, 2014 Sep 5. PMID 25014418
    3. Resveratrol-Loaded Lipid Nanocarriers Are Internalized By Endocytosis in Yeast. Barbosa C, et al. J Nat Prod, 2019 May 24. PMID 30964667
    4. In vitro, in vivo and in silico rationale for the muscle loss due to therapeutic drugs used in the treatment of Mycobacterium tuberculosis infection. Pathak S, et al. J Biomol Struct Dyn, 2022 Jan. PMID 32795137
    5. End3p-mediated endocytosis is required for spore wall formation in Saccharomyces cerevisiae. Morishita M, et al. Genetics, 2005 Aug. PMID 15944351, Free PMC Article

    See all (145) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The C-terminal End3 Repeats of End3 associate with the N-terminal part of Pan1's central coiled-coil region.
      Title: Targeted disruption of an EH-domain protein endocytic complex, Pan1-End3.
    2. END3-mediated endocytosis is required for spore wall formation.
      Title: End3p-mediated endocytosis is required for spore wall formation in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-macromolecule adaptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ascospore wall assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endosomal transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within reticulophagy IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in actin cortical patch IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of actin cytoskeleton-regulatory complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of actin cytoskeleton-regulatory complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cell periphery HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mating projection tip HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    End3p
    NP_014315.1
    • EH domain-containing protein involved in endocytosis; actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      470053..471102 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182922.1 → NP_014315.1  TPA: End3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014315.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W195, P39013, Q8TFC4, Q8TFD0, Q8TG51
      UniProtKB/TrEMBL
      C7GUN4, N1NXI0
      Conserved Domains (3) summary
      smart00027
      Location:123 → 221
      EH; Eps15 homology domain
      pfam12763
      Location:1 → 104
      EF-hand_4; Cytoskeletal-regulatory complex EF hand
      pfam12761
      Location:186 → 345
      End3; Actin cytoskeleton-regulatory complex protein END3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39013.1

    Gene LinkOut

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