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    ARC35 Arc35p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855771, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ARC35
    Official Full Name
    Arc35p
    Primary source
    SGD:S000005318
    Locus tag
    YNR035C
    See related
    AllianceGenome:SGD:S000005318; FungiDB:YNR035C; VEuPathDB:YNR035C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    END9
    Summary
    Enables calmodulin binding activity and molecular adaptor activity. Involved in cytoskeleton organization; protein localization to cell cortex; and receptor-mediated endocytosis. Located in cytosol. Part of Arp2/3 protein complex. Orthologous to human ARPC2 (actin related protein 2/3 complex subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ARC35 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (693019..694047, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Sol1p Neighboring gene Ego4p Neighboring gene putative mitochondrial 37S ribosomal protein MRPS12 Neighboring gene mitochondrial 37S ribosomal protein RSM19

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The intrinsically disordered region of coronins fine-tunes oligomerization and actin polymerization. Han X, et al. Cell Rep, 2023 Jun 27. PMID 37269287
    2. Functional interactions between the p35 subunit of the Arp2/3 complex and calmodulin in yeast. Schaerer-Brodbeck C, et al. Mol Biol Cell, 2000 Apr. PMID 10749918, Free PMC Article
    3. Saccharomyces cerevisiae Arc35p works through two genetically separable calmodulin functions to regulate the actin and tubulin cytoskeletons. Schaerer-Brodbeck C, et al. J Cell Sci, 2000 Feb. PMID 10639338
    4. GMF is a cofilin homolog that binds Arp2/3 complex to stimulate filament debranching and inhibit actin nucleation. Gandhi M, et al. Curr Biol, 2010 May 11. PMID 20362448, Free PMC Article
    5. Affinity filtration coupled with capillary-based affinity purification for the isolation of protein complexes. Qureshi MS, et al. Anal Biochem, 2013 Aug 1. PMID 23583819

    See all (72) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables molecular adaptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables structural constituent of cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Arp2/3 complex-mediated actin nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Arp2/3 complex-mediated actin nucleation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in actin cortical patch organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in actin filament polymerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in microtubule cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to cell cortex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in receptor-mediated endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Arp2/3 protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Arp2/3 protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Arp2/3 protein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in actin cortical patch IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Arc35p
    NP_014433.1
    • Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      693019..694047 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183212.1 → NP_014433.1  TPA: Arc35p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014433.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1L1, P53731
      UniProtKB/TrEMBL
      A6ZSB0, B3LPK7, B5VR64, C7GLM1, C8ZFR4, G2WL93, N1NZR7
      Conserved Domains (1) summary
      pfam04045
      Location:56 → 316
      P34-Arc; Arp2/3 complex, 34 kD subunit p34-Arc
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53731.1

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