SLK19 Slk19p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SLK19
Official Full Name: Slk19p
Primary source: SGD:S000005721
Locus tag: YOR195W
See related: AllianceGenome:SGD:S000005721; FungiDB:YOR195W; VEuPathDB:YOR195W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Involved in several processes, including centromere clustering; mitotic spindle organization; and positive regulation of exit from mitosis. Located in spindle midzone. Is active in kinetochore. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See SLK19 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (712866..715331)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Slk19 enhances cross-linking of microtubules by Ase1 and Stu1.
Title: Slk19 enhances cross-linking of microtubules by Ase1 and Stu1.
Centromere clustering is achieved at least by two parallel pathways, through Dam1 and another via Slk19.
Title: Outer kinetochore protein Dam1 promotes centromere clustering in parallel with Slk19 in budding yeast.
Slk19 role in the regulation pericentric cohesin and anaphase onset.
Title: Cdk1 phosphorylation of Esp1/Separase functions with PP2A and Slk19 to regulate pericentric Cohesin and anaphase onset.
Therefore Slk19 likely acts as kinetochore glue that clusters kinetochores to facilitate efficient and faithful chromosome segregation.
Title: Slk19 clusters kinetochores and facilitates chromosome bipolar attachment.
in early anaphase one region of Slk19p is essential for FEAR signaling, while later in anaphase another region is critical for maintaining the coordination between spindle elongation and the growth of interpolar microtubules.
Title: Slk19p of Saccharomyces cerevisiae regulates anaphase spindle dynamics through two independent mechanisms.
Deletion of SLK19, eliminated the mid-anaphase pause, caused premature anaphase onset and defects in DNA division during anaphase, and reduced viability in kinesin-5-mutated cells
Title: Slk19-dependent mid-anaphase pause in kinesin-5-mutated cells.
Slk19 participates in regulating nuclear migration and, in conjunction with cohesin complex, may be involved in the maintenance of centromeric tensile strength to resist the pole-ward pull.
Title: Deficiency of centromere-associated protein Slk19 causes premature nuclear migration and loss of centromeric elasticity.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in centromere clustering	IDA Inferred from Direct Assay more info	PubMed
involved_in centromere clustering	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromosome segregation	IEA Inferred from Electronic Annotation more info
involved_in chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in meiotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of exit from mitosis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of exit from mitosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to chromosome, centromeric region	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome, centromeric region	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in kinetochore	IDA Inferred from Direct Assay more info	PubMed
located_in kinetochore	IDA Inferred from Direct Assay more info	PubMed
located_in kinetochore	IEA Inferred from Electronic Annotation more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in spindle	IDA Inferred from Direct Assay more info	PubMed
located_in spindle midzone	IDA Inferred from Direct Assay more info	PubMed
located_in spindle pole body	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Slk19p

NP_014838.3

Kinetochore-associated protein; required for chromosome segregation and kinetochore clustering; required for normal segregation of chromosomes in meiosis and mitosis; component of the FEAR regulatory network, which promotes Cdc14p release from the nucleolus during anaphase; potential Cdc28p substrate

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

712866..715331

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183614.3 → NP_014838.3 TPA: Slk19p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014838.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W2Q4, Q08581

UniProtKB/TrEMBL

N1NX48, U3N747, U3N7R7

Conserved Domains (4) summary

COG1196
Location:462 → 821

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

PTZ00482
Location:25 → 185

PTZ00482; membrane-attack complex/perforin (MACPF) Superfamily; Provisional

TIGR02168
Location:249 → 623

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam12709
Location:742 → 818

Kinetocho_Slk19; Central kinetochore-associated