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    sigE ECF RNA polymerase sigma factor SigE [ Mycobacterium tuberculosis H37Rv ]

    Gene ID: 888751, updated on 6-Oct-2023

    Summary

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    Gene symbol
    sigE
    Gene description
    ECF RNA polymerase sigma factor SigE
    Locus tag
    Rv1221
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
    Lineage
    Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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    Genomic context

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    Sequence:
    NC_000962.3 (1364413..1365186)

    NC_000962.3Genomic Context describing neighboring genes Neighboring gene tetronasin ABC transporter ATP-binding protein Neighboring gene transcriptional regulator Neighboring gene methyltransferase Neighboring gene anti-sigma E factor RseA Neighboring gene serine protease HtrA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000962.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mycobacterium tuberculosis sigE mutant ST28 used as a vaccine induces protective immunity in the guinea pig model. Troudt J, et al. Tuberculosis (Edinb), 2017 Sep. PMID 28802412, Free PMC Article
    2. Mycobacterium tuberculosis sigma factor E regulon modulates the host inflammatory response. Fontán PA, et al. J Infect Dis, 2008 Sep 15. PMID 18657035
    3. Assessing the role of Rv1222 (RseA) as an anti-sigma factor of the Mycobacterium tuberculosis extracytoplasmic sigma factor SigE. Boldrin F, et al. Sci Rep, 2019 Mar 14. PMID 30872756, Free PMC Article
    4. The Alternative Sigma Factors SigE and SigB Are Involved in Tolerance and Persistence to Antitubercular Drugs. Pisu D, et al. Antimicrob Agents Chemother, 2017 Dec. PMID 28993339, Free PMC Article
    5. Critical role of a single position in the -35 element for promoter recognition by Mycobacterium tuberculosis SigE and SigH. Song T, et al. J Bacteriol, 2008 Mar. PMID 18192397, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Assessing the role of Rv1222 (RseA) as an anti-sigma factor of the Mycobacterium tuberculosis extracytoplasmic sigma factor SigE.
      Title: Assessing the role of Rv1222 (RseA) as an anti-sigma factor of the Mycobacterium tuberculosis extracytoplasmic sigma factor SigE.
    2. Mycobacterium tuberculosis mutant missing the gene encoding for the extracellular function sigma factor SigE, is strongly attenuated and is able to induce an effective protection from M. tuberculosis infection.
      Title: Mycobacterium tuberculosis sigE mutant ST28 used as a vaccine induces protective immunity in the guinea pig model.
    3. The alternative sigma factors SigE and SigB are involved in tolerance and persistence to antitubercular drugs in Mycobacterium tuberculosis.
      Title: The Alternative Sigma Factors SigE and SigB Are Involved in Tolerance and Persistence to Antitubercular Drugs.
    4. Authors describe the regulatory architecture of a signal transduction system involving the two-component system SenX3-RegX3, the extracytoplasmic function sigma factor sigma E and the poly P-synthesizing enzyme polyphosphate kinase 1.
      Title: Polyphosphate kinase 1, a central node in the stress response network of Mycobacterium tuberculosis, connects the two-component systems MprAB and SenX3-RegX3 and the extracytoplasmic function sigma factor, sigma E.
    5. The SigE regulon is involved in the modulation of the inflammatory response in Mycobacterium tuberculosis infection.
      Title: Mycobacterium tuberculosis sigma factor E regulon modulates the host inflammatory response.
    6. Data demonstrate that sigma(E) not only is subjected to complex transcriptional regulation but is also controlled at the translational and posttranslational levels.
      Title: Evidence of complex transcriptional, translational, and posttranslational regulation of the extracytoplasmic function sigma factor sigmaE in Mycobacterium tuberculosis.
    7. Data determined that SigE recognize nearly identical promoters as sigB, with differences at the 3' end of the -35 element distinguishing between SigE- and SigH-dependent promoters.
      Title: Critical role of a single position in the -35 element for promoter recognition by Mycobacterium tuberculosis SigE and SigH.
    8. Response regulator MprA bound to conserved motifs in the upstream regions of both sigB and sigE in vitro and regulated the in vivo expression of sigB and sigE in M. tuberculosis.
      Title: MprAB is a stress-responsive two-component system that directly regulates expression of sigma factors SigB and SigE in Mycobacterium tuberculosis.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    General protein information

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    Preferred Names
    ECF RNA polymerase sigma factor SigE
    NP_215737.1
    • alternative sigma factor of extracytoplasmic function (ECF) family

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000962.3 Reference assembly

      Range
      1364413..1365186
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_215737.1 ECF RNA polymerase sigma factor SigE [Mycobacterium tuberculosis H37Rv]

      See identical proteins and their annotated locations for NP_215737.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2I7W5W8
      Conserved Domains (1) summary
      PRK09647
      Location:55 → 257
      PRK09647; RNA polymerase sigma factor SigE; Reviewed
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P9WGG7.1

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