RPT3 proteasome regulatory particle base subunit RPT3 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: RPT3
Official Full Name: proteasome regulatory particle base subunit RPT3
Primary source: SGD:S000002802
Locus tag: YDR394W
See related: AllianceGenome:SGD:S000002802; FungiDB:YDR394W; VEuPathDB:YDR394W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: YNT1; YTA2
Summary: Predicted to enable ATP hydrolysis activity and proteasome-activating activity. Involved in positive regulation of RNA polymerase II transcription preinitiation complex assembly; proteasome regulatory particle assembly; and ubiquitin-dependent protein catabolic process. Part of proteasome regulatory particle, base subcomplex. Used to study hereditary spastic paraplegia. Orthologous to human PSMC4 (proteasome 26S subunit, ATPase 4). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See RPT3 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (1261681..1262967)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that both ATPases Rpt6 and Rpt3 tails are required for the eviction of Nas6 chaperone upon proteasome assembly.
Title: Proteasome Activation is Mediated via a Functional Switch of the Rpt6 C-terminal Tail Following Chaperone-dependent Assembly.
provide a structural basis for the association between Nas6 and the heterohexameric ATPase ring of the proteasome through Rpt3
Title: Structural basis for the recognition between the regulatory particles Nas6 and Rpt3 of the yeast 26S proteasome.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables proteasome-activating activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in positive regulation of RNA polymerase II transcription preinitiation complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of macromolecule metabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of proteasomal protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in proteasomal protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in proteasome regulatory particle assembly	IEA Inferred from Electronic Annotation more info
involved_in proteasome regulatory particle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of proteasome complex	IEA Inferred from Electronic Annotation more info
part_of proteasome regulatory particle, base subcomplex	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome regulatory particle, base subcomplex	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome regulatory particle, base subcomplex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: proteasome regulatory particle base subunit RPT3

NP_010682.3

ATPase of the 19S regulatory particle of the 26S proteasome; one of ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; substrate of N-acetyltransferase B

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

1261681..1262967

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180702.3 → NP_010682.3 TPA: proteasome regulatory particle base subunit RPT3 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010682.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VT28, P33298

UniProtKB/TrEMBL

A6ZYZ5, B3LFQ6, B5VGS6, C7GSC8, C8Z5V8, G2WBD4, N1PAJ3

Conserved Domains (1) summary

PTZ00454
Location:46 → 428

PTZ00454; 26S protease regulatory subunit 6B-like protein; Provisional