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    TFC4 transcription factor TFIIIC subunit TFC4 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852938, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TFC4
    Official Full Name
    transcription factor TFIIIC subunit TFC4
    Primary source
    SGD:S000003279
    Locus tag
    YGR047C
    See related
    AllianceGenome:SGD:S000003279; FungiDB:YGR047C; VEuPathDB:YGR047C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    PCF1
    Summary
    Contributes to DNA binding activity, bending; RNA polymerase III type 1 promoter sequence-specific DNA binding activity; and RNA polymerase III type 2 promoter sequence-specific DNA binding activity. Involved in 5S class rRNA transcription by RNA polymerase III. Located in cytoplasm and nucleus. Part of transcription factor TFIIIC complex. Orthologous to human GTF3C3 (general transcription factor IIIC subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See TFC4 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (586392..589469, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene putative phosphatidate cytidylyltransferase Neighboring gene polyubiquitin-binding protein UFD1 Neighboring gene Scm4p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The PCF1-1 mutation increases the activity of the transcription factor (TF) IIIB fraction from Saccharomyces cerevisiae. Willis I, et al. Nucleic Acids Res, 1992 Jul 25. PMID 1641338, Free PMC Article
    2. Autoinhibition of TFIIIB70 binding by the tetratricopeptide repeat-containing subunit of TFIIIC. Moir RD, et al. J Biol Chem, 2002 Jan 4. PMID 11684692
    3. Absolute gene occupancies by RNA polymerase III, TFIIIB, and TFIIIC in Saccharomyces cerevisiae. Soragni E, et al. J Biol Chem, 2008 Sep 26. PMID 18667429, Free PMC Article
    4. A tetratricopeptide repeat mutation in yeast transcription factor IIIC131 (TFIIIC131) facilitates recruitment of TFIIB-related factor TFIIIB70. Moir RD, et al. Mol Cell Biol, 1997 Dec. PMID 9372943, Free PMC Article
    5. The TFIIIB-assembling subunit of yeast transcription factor TFIIIC has both tetratricopeptide repeats and basic helix-loop-helix motifs. Marck C, et al. Proc Natl Acad Sci U S A, 1993 May 1. PMID 8387209, Free PMC Article

    See all (84) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The data are consistent with this peptide causing a conformational change in TFIIIC that overcomes Tfc4 autoinhibition of Brf1 binding and suggest a structural model for the Brf1-Tfc4 interaction.
      Title: Interactions of Brf1 peptides with the tetratricopeptide repeat-containing subunit of TFIIIC inhibit and promote preinitiation complex assembly.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to DNA binding, bending IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to RNA polymerase III type 1 promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to RNA polymerase III type 2 promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 5S class rRNA transcription by RNA polymerase III IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transcription by RNA polymerase III IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription by RNA polymerase III IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transcription by RNA polymerase III IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription by RNA polymerase III IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription factor TFIIIC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIIIC complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transcription factor TFIIIC subunit TFC4
    NP_011561.3
    • Subunit of RNA polymerase III transcription initiation factor complex; one of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA domain of TFIIIC that binds BoxA DNA promoter sites of tRNA and similar genes; has TPR motifs; human homolog is TFIIIC-102

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      586392..589469 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181176.3 → NP_011561.3  TPA: transcription factor TFIIIC subunit TFC4 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011561.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUI4, P33339, Q45U37
      UniProtKB/TrEMBL
      A6ZV34, B3LIH4, B5VIZ9, C7GXN2, G2WED6, N1P3U8
      Conserved Domains (2) summary
      TIGR02917
      Location:124 → 551
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:197 → 224
      TPR; TPR repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P33339.1

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