Pacs1 phosphofurin acidic cluster sorting protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pacs1provided by RGD
Official Full Name: phosphofurin acidic cluster sorting protein 1provided by RGD
Primary source: RGD:620579
See related: EnsemblRapid:ENSRNOG00000020350 AllianceGenome:RGD:620579
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pacs-1
Summary: Predicted to enable transmembrane transporter binding activity. Predicted to be involved in lymphocyte homeostasis and protein localization to plasma membrane. Predicted to act upstream of or within protein localization to Golgi apparatus. Located in perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in Schuurs-Hoeijmakers Syndrome. Orthologous to human PACS1 (phosphofurin acidic cluster sorting protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 61.4), Testes (RPKM 61.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q43

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (211866872..211998828, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (202437503..202569473, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (220515117..220645611, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI576331 (e-PCR)
- UniSTS:248615

F11r (e-PCR), detects polymorphism
- UniSTS:516175

RH128831 (e-PCR)
- UniSTS:212139

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables transmembrane transporter binding	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter binding	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in lymphocyte homeostasis	IEA Inferred from Electronic Annotation more info
involved_in lymphocyte homeostasis	ISO Inferred from Sequence Orthology more info
involved_in lymphocyte homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to Golgi apparatus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein localization to Golgi apparatus	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in COPI-coated vesicle	IEA Inferred from Electronic Annotation more info
located_in COPI-coated vesicle	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: phosphofurin acidic cluster sorting protein 1

Names: cytosolic sorting protein PACS-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.