Olr59 olfactory receptor 59 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Olr59provided by RGD
Official Full Name: olfactory receptor 59provided by RGD
Primary source: RGD:628858
See related: EnsemblRapid:ENSRNOG00000018606 AllianceGenome:RGD:628858
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RA1c; Olfr78; Or51e2
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]
Expression: Biased expression in Liver (RPKM 32.2), Kidney (RPKM 11.6) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q32

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (166604972..166639634, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (157193051..157227707, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (167906030..167940688, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overexpression of olfactory receptor 78 ameliorates brain injury in cerebral ischaemia-reperfusion rats by activating Prkaca-mediated cAMP/PKA-MAPK pathway.
Title: Overexpression of olfactory receptor 78 ameliorates brain injury in cerebral ischaemia-reperfusion rats by activating Prkaca-mediated cAMP/PKA-MAPK pathway.
Among the up-regulated hepatic genes that were identified, the expression of Olr59, Ethe1, and Slc10a2 increased specifically in rats neonatally exposed to triiodothyronine.
Title: Altered expression of the Olr59, Ethe1, and Slc10a2 genes in the liver of F344 rats by neonatal thyroid hormone disruption.
expressed only in distinct regions of the brain and in addition ina defined zone of the olfactory epithelium.
Title: Identification of a novel G-protein coupled receptor expressed in distinct brain regions and a defined olfactory zone.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables nuclear steroid receptor activity	IEA Inferred from Electronic Annotation more info
enables nuclear steroid receptor activity	ISO Inferred from Sequence Orthology more info
enables nuclear steroid receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables olfactory receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables olfactory receptor activity	IEA Inferred from Electronic Annotation more info
enables olfactory receptor activity	ISO Inferred from Sequence Orthology more info
enables olfactory receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables signaling receptor activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell migration	IEA Inferred from Electronic Annotation more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to fatty acid	IEA Inferred from Electronic Annotation more info
involved_in cellular response to fatty acid	ISO Inferred from Sequence Orthology more info
involved_in cellular response to fatty acid	ISS Inferred from Sequence or Structural Similarity more info
involved_in detection of chemical stimulus involved in sensory perception of smell	IEA Inferred from Electronic Annotation more info
involved_in melanocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in melanocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in melanocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in melanocyte proliferation	IEA Inferred from Electronic Annotation more info
involved_in melanocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in melanocyte proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of blood pressure	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of blood pressure	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of renin secretion into blood stream	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of renin secretion into blood stream	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of renin secretion into blood stream	ISS Inferred from Sequence or Structural Similarity more info
involved_in steroid hormone receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in steroid hormone receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in steroid hormone receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
located_in early endosome membrane	ISO Inferred from Sequence Orthology more info
located_in early endosome membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: olfactory receptor 51E2

Names: G-protein coupled receptor RA1c; olfactory receptor 78

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_173293.2 → NP_775415.2 olfactory receptor 51E2

Status: REVIEWED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

O88628

UniProtKB/TrEMBL

A6I763, G3V8E6

Conserved Domains (1) summary

cd15222
Location:24 → 298

7tmA_OR51-like; olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

166604972..166639634 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008759671.2 → XP_008757893.1 olfactory receptor 51E2 isoform X1

See identical proteins and their annotated locations for XP_008757893.1

UniProtKB/Swiss-Prot

O88628

UniProtKB/TrEMBL

A6I763, G3V8E6

Conserved Domains (1) summary

cd15222
Location:24 → 298

7tmA_OR51-like; olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_008759669.4 → XP_008757891.1 olfactory receptor 51E2 isoform X1

See identical proteins and their annotated locations for XP_008757891.1

UniProtKB/Swiss-Prot

O88628

UniProtKB/TrEMBL

A6I763, G3V8E6

Related

ENSRNOP00000105716.1, ENSRNOT00000169520.1

Conserved Domains (1) summary

cd15222
Location:24 → 298

7tmA_OR51-like; olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_008759670.4 → XP_008757892.1 olfactory receptor 51E2 isoform X1

See identical proteins and their annotated locations for XP_008757892.1

UniProtKB/Swiss-Prot

O88628

UniProtKB/TrEMBL

A6I763, G3V8E6

Conserved Domains (1) summary

cd15222
Location:24 → 298

7tmA_OR51-like; olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors