U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Kcnj1 potassium inwardly-rectifying channel, subfamily J, member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24521, updated on 27-Nov-2024

    Summary

    Symbol
    Kcnj1provided by RGD
    Full Name
    potassium inwardly-rectifying channel, subfamily J, member 1provided by RGD
    Primary source
    RGD:2957
    See related
    EnsemblRapid:ENSRNOG00000059005 AllianceGenome:RGD:2957
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Kcnj; KAB-1; ROMK1; ROMK2; ROMK3; kir1.1; Kcnj1_v1; Kcnj1_v3
    Summary
    Enables several functions, including ATP binding activity; ATP-activated inward rectifier potassium channel activity; and potassium ion binding activity. Involved in several processes, including cellular response to magnesium ion; potassium ion import across plasma membrane; and response to potassium ion. Predicted to be part of monoatomic ion channel complex. Predicted to be active in plasma membrane. Biomarker of nephrotic syndrome. Human ortholog(s) of this gene implicated in Bartter disease type 2. Orthologous to human KCNJ1 (potassium inwardly rectifying channel subfamily J member 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 575.3) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Kcnj1 in Genome Data Viewer
    Location:
    8q21
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (39014822..39066716)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (30779883..30808607)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (33490280..33519127)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 32 Neighboring gene ribosomal protein L35 like 2 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 5 Neighboring gene Fli-1 proto-oncogene, ETS transcription factor Neighboring gene uncharacterized LOC134479972

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in cellular response to magnesium ion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within circulatory system development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within kidney development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within post-embryonic development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in potassium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in potassium ion import across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in potassium ion import across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in potassium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in potassium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of G-protein activated inward rectifier potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of monoatomic ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within renal sodium ion absorption ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to potassium ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within tissue homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of monoatomic ion channel complex IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ATP-sensitive inward rectifier potassium channel 1
    Names
    ATP-regulated potassium channel ROM-K
    K+ channel protein
    inward rectifier K(+) channel Kir1.1
    potassium channel, inwardly rectifying subfamily J member 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001309297.1NP_001296226.1  ATP-sensitive inward rectifier potassium channel 1 isoform 2

      See identical proteins and their annotated locations for NP_001296226.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2, also known as ROMK2) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      O88639, O88640, P35560, Q9QUR5
      UniProtKB/TrEMBL
      A0A8I6AW52, A6JYI0
      Related
      ENSRNOP00000077878.2, ENSRNOT00000110096.2
      Conserved Domains (1) summary
      pfam01007
      Location:24352
      IRK; Inward rectifier potassium channel
    2. NM_001309298.1NP_001296227.1  ATP-sensitive inward rectifier potassium channel 1 isoform 3

      See identical proteins and their annotated locations for NP_001296227.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3, also known as ROMK6.1) contains two alternate exons in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 3 which has a shorter N-terminus compared to isoform 1. Variants 3, 4 and 5 encode the same protein (isoform 3).
      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A0G2K298, A6JYI4
      Related
      ENSRNOP00000072157.2, ENSRNOT00000081525.3
      Conserved Domains (1) summary
      cl21560
      Location:1198
      Ion_trans_2; Ion channel
    3. NM_001309299.1NP_001296228.1  ATP-sensitive inward rectifier potassium channel 1 isoform 3

      See identical proteins and their annotated locations for NP_001296228.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4, also known as ROMK3.1) contains three alternate exons in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 3 which has a shorter N-terminus compared to isoform 1. Variants 3, 4 and 5 encode the same protein (isoform 3).
      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A0G2K298, A6JYI4
      Related
      ENSRNOP00000078843.2, ENSRNOT00000099372.2
      Conserved Domains (1) summary
      cl21560
      Location:1198
      Ion_trans_2; Ion channel
    4. NM_001309301.1NP_001296230.1  ATP-sensitive inward rectifier potassium channel 1 isoform 3

      See identical proteins and their annotated locations for NP_001296230.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5, also known as ROMK1.1) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 3 which has a shorter N-terminus compared to isoform 1. Variants 3, 4 and 5 encode the same protein (isoform 3).
      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A0G2K298, A6JYI4
      Conserved Domains (1) summary
      cl21560
      Location:1198
      Ion_trans_2; Ion channel
    5. NM_017023.2NP_058719.2  ATP-sensitive inward rectifier potassium channel 1 isoform 1

      See identical proteins and their annotated locations for NP_058719.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1, also known as ROMK1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      O88639, O88640, P35560, Q9QUR5
      UniProtKB/TrEMBL
      A0A0G2JYW2, A6JYH9
      Related
      ENSRNOP00000070813.1, ENSRNOT00000081614.3
      Conserved Domains (1) summary
      pfam01007
      Location:43371
      IRK; Inward rectifier potassium channel

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      39014822..39066716
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063264896.1XP_063120966.1  ATP-sensitive inward rectifier potassium channel 1 isoform X1

    2. XM_063264899.1XP_063120969.1  ATP-sensitive inward rectifier potassium channel 1 isoform X3

    3. XM_063264898.1XP_063120968.1  ATP-sensitive inward rectifier potassium channel 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZJL6
    4. XM_063264897.1XP_063120967.1  ATP-sensitive inward rectifier potassium channel 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZJL6