Chka choline kinase alpha [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Chkaprovided by RGD
Official Full Name: choline kinase alphaprovided by RGD
Primary source: RGD:61944
See related: EnsemblRapid:ENSRNOG00000016791 AllianceGenome:RGD:61944
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Chk; CK-R
Summary: Enables ATP binding activity; choline binding activity; and phosphotransferase activity, alcohol group as acceptor. Involved in several processes, including choline metabolic process; ethanolamine metabolic process; and response to 3-methylcholanthrene. Predicted to be located in lipid droplet. Predicted to be active in cytosol. Biomarker of colon cancer and transient cerebral ischemia. Orthologous to human CHKA (choline kinase alpha). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 135.0), Spleen (RPKM 97.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q43

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (210506069..210554753)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (201076804..201125517)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (219076618..219126221)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

RH125233 (e-PCR)
- UniSTS:162055

AA892051 (e-PCR)
- UniSTS:250691

D1Wox63 (e-PCR)
- UniSTS:239567

UniSTS:225274 (e-PCR)
- UniSTS:225274

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables choline binding	IDA Inferred from Direct Assay more info	PubMed
enables choline kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables choline kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables choline kinase activity	IEA Inferred from Electronic Annotation more info
enables choline kinase activity	ISO Inferred from Sequence Orthology more info
enables choline kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables choline kinase activity	TAS Traceable Author Statement more info	PubMed
enables cholinesterase activity	IEA Inferred from Electronic Annotation more info
enables cholinesterase activity	ISO Inferred from Sequence Orthology more info
enables ethanolamine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ethanolamine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables ethanolamine kinase activity	IEA Inferred from Electronic Annotation more info
enables ethanolamine kinase activity	ISO Inferred from Sequence Orthology more info
enables ethanolamine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone H2AXY142 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3Y41 kinase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in CDP-choline pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in CDP-choline pathway	IEA Inferred from Electronic Annotation more info
involved_in cellular response to glucose starvation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glucose starvation	ISS Inferred from Sequence or Structural Similarity more info
involved_in choline metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in ethanolamine metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_positive_effect lipid droplet disassembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_positive_effect lipid droplet disassembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within phosphatidylcholine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylcholine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylcholine biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphatidylethanolamine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylethanolamine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylethanolamine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylethanolamine biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to 3-methylcholanthrene	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to toxic substance	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in lipid droplet	IEA Inferred from Electronic Annotation more info
located_in lipid droplet	ISO Inferred from Sequence Orthology more info
located_in lipid droplet	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: choline kinase alpha

Names: CHETK-alpha; CK; EK; choline kinase R; ethanolamine kinase

NP_001385515.1

EC 2.7.1.32

EC 2.7.1.82

NP_058823.1

EC 2.7.1.32

EC 2.7.1.82

XP_006230769.1

EC 2.7.1.32

EC 2.7.1.82

XP_008758312.1

EC 2.7.1.32

EC 2.7.1.82

XP_038959024.1

EC 2.7.1.32

EC 2.7.1.82

XP_038959032.1

EC 2.7.1.32

EC 2.7.1.82

XP_038959042.1

EC 2.7.1.32

EC 2.7.1.82

XP_038959045.1

EC 2.7.1.32

EC 2.7.1.82

XP_038959050.1

EC 2.7.1.32

EC 2.7.1.82

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001398586.1 → NP_001385515.1 choline kinase alpha isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

Q01134, Q63114

UniProtKB/TrEMBL

A6HYM1

Related

ENSRNOP00000023020.3, ENSRNOT00000023020.9

Conserved Domains (1) summary

cd05156
Location:107 → 448

ChoK_euk; Euykaryotic Choline Kinase
NM_017127.3 → NP_058823.1 choline kinase alpha isoform 2

See identical proteins and their annotated locations for NP_058823.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

Q66HK1

Related

ENSRNOP00000022824.4, ENSRNOT00000022824.8

Conserved Domains (2) summary

PLN02236
Location:95 → 433

PLN02236; choline kinase

cd05156
Location:107 → 430

ChoK_euk; Euykaryotic Choline Kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

210506069..210554753

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006230707.5 → XP_006230769.1 choline kinase alpha isoform X1

UniProtKB/TrEMBL

A0A8I6AJV1

Related

ENSRNOP00000088950.1, ENSRNOT00000096831.2

Conserved Domains (2) summary

PLN02236
Location:95 → 461

PLN02236; choline kinase

cd05156
Location:107 → 458

ChoK_euk; Euykaryotic Choline Kinase
XM_039103104.2 → XP_038959032.1 choline kinase alpha isoform X3

Conserved Domains (1) summary

cd05156
Location:62 → 343

ChoK_euk; Euykaryotic Choline Kinase
XM_039103117.1 → XP_038959045.1 choline kinase alpha isoform X4

UniProtKB/TrEMBL

A6HYM6

Conserved Domains (1) summary

cd05156
Location:1 → 276

ChoK_euk; Euykaryotic Choline Kinase
XM_039103122.1 → XP_038959050.1 choline kinase alpha isoform X4

UniProtKB/TrEMBL

A6HYM6

Conserved Domains (1) summary

cd05156
Location:1 → 276

ChoK_euk; Euykaryotic Choline Kinase
XM_039103096.2 → XP_038959024.1 choline kinase alpha isoform X3

Conserved Domains (1) summary

cd05156
Location:62 → 343

ChoK_euk; Euykaryotic Choline Kinase
XM_008760090.3 → XP_008758312.1 choline kinase alpha isoform X2

See identical proteins and their annotated locations for XP_008758312.1

Conserved Domains (1) summary

cd05156
Location:125 → 406

ChoK_euk; Euykaryotic Choline Kinase
XM_039103114.2 → XP_038959042.1 choline kinase alpha isoform X4

UniProtKB/TrEMBL

A6HYM6

Conserved Domains (1) summary

cd05156
Location:1 → 276

ChoK_euk; Euykaryotic Choline Kinase