Ppp2r1a protein phosphatase 2 scaffold subunit A alpha [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ppp2r1aprovided by RGD
Official Full Name: protein phosphatase 2 scaffold subunit A alphaprovided by RGD
Primary source: RGD:620907
See related: EnsemblRapid:ENSRNOG00000011282 AllianceGenome:RGD:620907
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: PR65
Summary: Predicted to enable several functions, including protein antigen binding activity; protein heterodimerization activity; and protein phosphatase regulator activity. Predicted to be involved in several processes, including T cell homeostasis; negative regulation of intracellular signal transduction; and protein dephosphorylation. Predicted to act upstream of or within several processes, including nuclear division; peptidyl-serine dephosphorylation; and positive regulation of extrinsic apoptotic signaling pathway in absence of ligand. Predicted to be located in several cellular components, including chromosome, centromeric region; lateral plasma membrane; and neuronal cell body. Predicted to be part of FAR/SIN/STRIPAK complex and protein phosphatase type 2A complex. Predicted to be active in cytosol; glutamatergic synapse; and nucleus. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 36. Orthologous to human PPP2R1A (protein phosphatase 2 scaffold subunit Aalpha). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 681.0), Heart (RPKM 498.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q12

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (69213198..69232441)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (60540223..60559467)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (60717386..60736629)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PR65A phosphorylation regulates PP2A complex signaling.
Title: PR65A phosphorylation regulates PP2A complex signaling.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ppp2r1a (e-PCR), detects polymorphism
- UniSTS:526874

Ppp2r1a (e-PCR), detects polymorphism
- UniSTS:526875

Ppp2r1b (e-PCR), detects polymorphism
- UniSTS:526876

BF390652 (e-PCR)
- UniSTS:249515

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein antigen binding	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein phosphatase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine phosphatase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in T cell homeostasis	ISO Inferred from Sequence Orthology more info
involved_in chromosome segregation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within female meiotic nuclear division	ISO Inferred from Sequence Orthology more info
involved_in meiotic sister chromatid cohesion, centromeric	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within meiotic sister chromatid cohesion, centromeric	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within meiotic spindle elongation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mitotic sister chromatid separation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of hippo signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within peptidyl-serine dephosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of meiotic cell cycle process involved in oocyte maturation	ISO Inferred from Sequence Orthology more info
involved_in spindle assembly	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of FAR/SIN/STRIPAK complex	ISO Inferred from Sequence Orthology more info
located_in chromosome, centromeric region	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in lateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein phosphatase type 2A complex	IBA Inferred from Biological aspect of Ancestor more info
part_of protein phosphatase type 2A complex	ISO Inferred from Sequence Orthology more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

Names: protein phosphatase 2, regulatory subunit A, alpha

NP_476481.1

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_057140.1 → NP_476481.1 serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

See identical proteins and their annotated locations for NP_476481.1

Status: PROVISIONAL

Source sequence(s)

BC083859

UniProtKB/TrEMBL

F7EWM3, Q5XI34

Related

ENSRNOP00000015019.4, ENSRNOT00000015019.8

Conserved Domains (3) summary

COG1413
Location:187 → 462

HEAT; HEAT repeat [General function prediction only]

sd00044
Location:245 → 269

HEAT; HEAT repeat [structural motif]

pfam02985
Location:166 → 196

HEAT; HEAT repeat