Abat 4-aminobutyrate aminotransferase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Abatprovided by RGD
Official Full Name: 4-aminobutyrate aminotransferaseprovided by RGD
Primary source: RGD:620948
See related: EnsemblRapid:ENSRNOG00000002636 AllianceGenome:RGD:620948
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gabat; beta-AlaAT
Summary: Enables 4-aminobutyrate:2-oxoglutarate transaminase activity. Involved in several processes, including gamma-aminobutyric acid biosynthetic process; positive regulation of inhibitory postsynaptic potential; and regulation of secretion. Located in mitochondrial matrix. Used to study several diseases, including Huntington's disease; depressive disorder; epilepsy (multiple); heroin dependence; and ischemia. Biomarker of Parkinsonism. Human ortholog(s) of this gene implicated in Alzheimer's disease; GABA aminotransferase deficiency; and Huntington's disease. Orthologous to human ABAT (4-aminobutyrate aminotransferase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 378.6), Kidney (RPKM 369.5) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q12

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (7503351..7599474, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (6996688..7092835, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (7093406..7200439, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of 4-aminobutyrate aminotransferase protects against injury-induced osteoarthritis in mice.
Title: Inhibition of 4-aminobutyrate aminotransferase protects against injury-induced osteoarthritis in mice.
Daytime restricted feeding influences the daily variations of GABA-T mRNA levels, stability, and catalytic activity of GABA-T.
Title: Synchronization by food access modifies the daily variations in expression and activity of liver GABA transaminase.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables (S)-3-amino-2-methylpropionate transaminase activity	IEA Inferred from Electronic Annotation more info
enables 4-aminobutyrate:2-oxoglutarate transaminase activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to 4-aminobutyrate:2-oxoglutarate transaminase activity	ISO Inferred from Sequence Orthology more info
enables 4-aminobutyrate:2-oxoglutarate transaminase activity	ISO Inferred from Sequence Orthology more info
contributes_to 4-aminobutyrate:2-oxoglutarate transaminase activity	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables iron-sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables pyridoxal phosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info
enables pyridoxal phosphate binding	ISO Inferred from Sequence Orthology more info
enables pyridoxal phosphate binding	ISS Inferred from Sequence or Structural Similarity more info
enables succinate-semialdehyde dehydrogenase binding	ISO Inferred from Sequence Orthology more info
enables succinate-semialdehyde dehydrogenase binding	ISS Inferred from Sequence or Structural Similarity more info
enables transaminase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in behavioral response to cocaine	ISO Inferred from Sequence Orthology more info
involved_in cerebellum development	IEP Inferred from Expression Pattern more info	PubMed
involved_in copulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in exploration behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gamma-aminobutyric acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gamma-aminobutyric acid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in gamma-aminobutyric acid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in gamma-aminobutyric acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of dopamine secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gamma-aminobutyric acid secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of aspartate secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of dopamine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of heat generation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of inhibitory postsynaptic potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of prolactin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of uterine smooth muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to cocaine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to ethanol	IDA Inferred from Direct Assay more info	PubMed
involved_in response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to iron ion	IDA Inferred from Direct Assay more info	PubMed
involved_in response to nicotine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to xenobiotic stimulus	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of 4-aminobutyrate transaminase complex	ISO Inferred from Sequence Orthology more info
part_of 4-aminobutyrate transaminase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: 4-aminobutyrate aminotransferase, mitochondrial

Names: (S)-3-amino-2-methylpropionate transaminase; GABA aminotransferase; GABA transaminase; GABA-AT; GABA-T; L-AIBAT; beta-AlaAT I; gamma-amino-N-butyrate transaminase

NP_112265.1

EC 2.6.1.19

EC 2.6.1.22

XP_006245822.1

EC 2.6.1.19

EC 2.6.1.22

XP_063126013.1

EC 2.6.1.19

EC 2.6.1.22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031003.2 → NP_112265.1 4-aminobutyrate aminotransferase, mitochondrial

See identical proteins and their annotated locations for NP_112265.1

Status: PROVISIONAL

Source sequence(s)

D87839

UniProtKB/TrEMBL

A0A8I6G7C5

Related

ENSRNOP00000003633.2, ENSRNOT00000003633.6

Conserved Domains (2) summary

TIGR00699
Location:34 → 496

GABAtrns_euk; 4-aminobutyrate aminotransferase, eukaryotic type

COG0160
Location:42 → 498

GabT; 4-aminobutyrate aminotransferase or related aminotransferase [Amino acid transport and metabolism]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

7503351..7599474 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006245760.5 → XP_006245822.1 4-aminobutyrate aminotransferase, mitochondrial isoform X1

See identical proteins and their annotated locations for XP_006245822.1

UniProtKB/Swiss-Prot

O70539, P50554, Q66HM1

UniProtKB/TrEMBL

A0A8I6G7C5, A6K4M1

Conserved Domains (2) summary

TIGR00699
Location:34 → 496

GABAtrns_euk; 4-aminobutyrate aminotransferase, eukaryotic type

COG0160
Location:42 → 498

GabT; 4-aminobutyrate aminotransferase or related aminotransferase [Amino acid transport and metabolism]
XM_063269943.1 → XP_063126013.1 4-aminobutyrate aminotransferase, mitochondrial isoform X1

UniProtKB/Swiss-Prot

O70539, P50554, Q66HM1

UniProtKB/TrEMBL

A6K4M1