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    NDL1 Ndl1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850956, updated on 9-Dec-2024

    Summary

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    Official Symbol
    NDL1
    Official Full Name
    Ndl1p
    Primary source
    SGD:S000004244
    Locus tag
    YLR254C
    See related
    AllianceGenome:SGD:S000004244; FungiDB:YLR254C; VEuPathDB:YLR254C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables microtubule plus-end binding activity. Involved in nuclear migration along microtubule. Located in cytoplasmic microtubule; nucleus; and peroxisome. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See NDL1 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (644404..644973, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene ethanol metabolism protein Neighboring gene Cqd2p Neighboring gene uncharacterized protein Neighboring gene Hap1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Lis1 acts as a "clutch" between the ATPase and microtubule-binding domains of the dynein motor. Huang J, et al. Cell, 2012 Aug 31. PMID 22939623, Free PMC Article
    2. NudEL targets dynein to microtubule ends through LIS1. Li J, et al. Nat Cell Biol, 2005 Jul. PMID 15965467, Free PMC Article
    3. Dynactin function in mitotic spindle positioning. Moore JK, et al. Traffic, 2008 Apr. PMID 18221362, Free PMC Article
    4. Systematic multi-level analysis of an organelle proteome reveals new peroxisomal functions. Yifrach E, et al. Mol Syst Biol, 2022 Sep. PMID 36164978, Free PMC Article
    5. Cnm1 mediates nucleus-mitochondria contact site formation in response to phospholipid levels. Eisenberg-Bord M, et al. J Cell Biol, 2021 Nov 1. PMID 34694322, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables microtubule plus-end binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear migration along microtubule IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear migration along microtubule IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Ndl1p
    NP_013355.1
    • Homolog of nuclear distribution factor NudE; NUDEL; interacts with Pac1p and regulates dynein targeting to microtubule plus ends; localizes to cytosol, nucleus and peroxisomes

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      644404..644973 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182141.1 → NP_013355.1  TPA: Ndl1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013355.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYQ1, Q06568
      UniProtKB/TrEMBL
      A7A1D6, B3RHD8, B5VNG8, G2WJ79, N1NYG8
      Conserved Domains (1) summary
      COG1196
      Location:6 → 121
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06568.1

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