GSY2 glycogen (starch) synthase GSY2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: GSY2
Official Full Name: glycogen (starch) synthase GSY2
Primary source: SGD:S000004248
Locus tag: YLR258W
See related: AllianceGenome:SGD:S000004248; FungiDB:YLR258W; VEuPathDB:YLR258W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity and glycogen binding activity. Involved in glycogen biosynthetic process. Located in cytoplasm. Human ortholog(s) of this gene implicated in cardiovascular system disease and glycogen storage disease. Orthologous to human GYS1 (glycogen synthase 1) and GYS2 (glycogen synthase 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See GSY2 in Genome Data Viewer

Location:: chromosome: XII

Exon count:: 1

Sequence:: Chromosome: XII; NC_001144.5 (660716..662833)

Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

When oxidized, the cysteine mutant glycogen synthase (GS) exhibits activity levels similar to the phosphorylated enzyme but cannot be activated by G-6-P, and upon reduction, the cysteine mutant GS regains normal activity levels and regulatory response to G-6-P activation.
Title: Redox Switch for the Inhibited State of Yeast Glycogen Synthase Mimics Regulation by Phosphorylation.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity	IBA Inferred from Biological aspect of Ancestor more info
enables alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity	IDA Inferred from Direct Assay more info	PubMed
enables alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity	IEA Inferred from Electronic Annotation more info
enables alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables glycogen binding	IDA Inferred from Direct Assay more info	PubMed
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in glycogen biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycogen biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in glycogen biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed

General protein information

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Preferred Names: glycogen (starch) synthase GSY2

NP_013359.1

EC 2.4.1.11

Glycogen synthase; expression induced by glucose limitation, nitrogen starvation, heat shock, and stationary phase; activity regulated by cAMP-dependent, Snf1p and Pho85p kinases as well as by the Gac1p-Glc7p phosphatase; GSY2 has a paralog, GSY1, that arose from the whole genome duplication; relocalizes from cytoplasm to plasma membrane upon DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001144.5 Reference assembly

Range

660716..662833

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182145.1 → NP_013359.1 TPA: glycogen (starch) synthase GSY2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013359.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VYQ5, P27472

UniProtKB/TrEMBL

A7A1D9, B3RHE1, C7GQY1, G2WJ83, N1NZH7

Conserved Domains (1) summary

cd03793
Location:7 → 616

GT3_GSY2-like; glycogen synthase GSY2 and similar proteins