Ampd1 adenosine monophosphate deaminase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ampd1provided by RGD
Official Full Name: adenosine monophosphate deaminase 1provided by RGD
Primary source: RGD:2109
See related: EnsemblRapid:ENSRNOG00000018656 AllianceGenome:RGD:2109
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ampd01; RATAMPD01
Summary: Enables AMP deaminase activity and myosin heavy chain binding activity. Involved in response to ATP. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in congestive heart failure and coronary artery disease. Orthologous to human AMPD1 (adenosine monophosphate deaminase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 2633.5) See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (193287219..193308446)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (190598707..190619938)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (205568934..205589961)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Adenosine monophosphate deaminase in the endoplasmic reticulum-mitochondria interface promotes mitochondrial Ca[2+] overload in type 2 diabetes rat hearts.
Title: Adenosine monophosphate deaminase in the endoplasmic reticulum-mitochondria interface promotes mitochondrial Ca(2+) overload in type 2 diabetes rat hearts.
Ultrastructural Localization of Histidine-rich Glycoprotein in Skeletal Muscle Fibers: Colocalization With AMP Deaminase.
Title: Ultrastructural Localization of Histidine-rich Glycoprotein in Skeletal Muscle Fibers: Colocalization With AMP Deaminase.

Submit: New GeneRIF Correction

General gene information

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Markers

AI553520 (e-PCR)
- UniSTS:164216

Ampd1 (e-PCR), detects polymorphism
- UniSTS:508561

RH94453 (e-PCR)
- UniSTS:119701

D2Wox37 (e-PCR)
- UniSTS:517847

D2Arb16 (e-PCR), detects polymorphism
- UniSTS:227314

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables AMP deaminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables AMP deaminase activity	IDA Inferred from Direct Assay more info	PubMed
enables AMP deaminase activity	IEA Inferred from Electronic Annotation more info
enables AMP deaminase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables myosin heavy chain binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in AMP metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in GMP salvage	IEA Inferred from Electronic Annotation more info
involved_in GMP salvage	ISO Inferred from Sequence Orthology more info
involved_in IMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in IMP salvage	IEA Inferred from Electronic Annotation more info
involved_in IMP salvage	ISO Inferred from Sequence Orthology more info
involved_in response to ATP	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: AMP deaminase 1

Names: Ampd; adenosine monophosphate deaminase 1 (isoform M); myoadenylate deaminase

NP_620231.1

EC 3.5.4.6

XP_006233122.1

EC 3.5.4.6

XP_038957689.1

EC 3.5.4.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_138876.1 → NP_620231.1 AMP deaminase 1

See identical proteins and their annotated locations for NP_620231.1

Status: PROVISIONAL

Source sequence(s)

J02811

UniProtKB/Swiss-Prot

P10759, Q6LDJ4

UniProtKB/TrEMBL

A0A8I6A1E3, A6K3K3

Related

ENSRNOP00000025248.7, ENSRNOT00000025248.8

Conserved Domains (2) summary

PLN03055
Location:131 → 742

PLN03055; AMP deaminase; Provisional

cd01319
Location:240 → 736

AMPD; AMP deaminase (AMPD) catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) at position 6 of the adenine nucleotide ring. AMPD is a diverse and highly regulated eukaryotic key enzyme of the adenylate catabolic pathway.

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

193287219..193308446

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006233060.5 → XP_006233122.1 AMP deaminase 1 isoform X2

See identical proteins and their annotated locations for XP_006233122.1

UniProtKB/TrEMBL

A0A8I6A1E3, A0A8L2QD93, A6K3K4

Related

ENSRNOP00000088318.2, ENSRNOT00000094047.2

Conserved Domains (2) summary

PLN03055
Location:127 → 738

PLN03055; AMP deaminase; Provisional

cd01319
Location:236 → 732

AMPD; AMP deaminase (AMPD) catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) at position 6 of the adenine nucleotide ring. AMPD is a diverse and highly regulated eukaryotic key enzyme of the adenylate catabolic pathway.
XM_039101761.2 → XP_038957689.1 AMP deaminase 1 isoform X1

UniProtKB/TrEMBL

A0A8I6A1E3

Related

ENSRNOP00000080039.2, ENSRNOT00000112496.2

Conserved Domains (1) summary

cd01319
Location:265 → 761

AMPD; AMP deaminase (AMPD) catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) at position 6 of the adenine nucleotide ring. AMPD is a diverse and highly regulated eukaryotic key enzyme of the adenylate catabolic pathway.