Ndrg2 NDRG family member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ndrg2provided by RGD
Official Full Name: NDRG family member 2provided by RGD
Primary source: RGD:621874
See related: EnsemblRapid:ENSRNOG00000010389 AllianceGenome:RGD:621874
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be involved in signal transduction and substantia nigra development. Predicted to act upstream of or within negative regulation of ERK1 and ERK2 cascade; negative regulation of vascular associated smooth muscle cell proliferation; and regulation of cytokine production. Predicted to be located in Golgi apparatus and nucleus. Predicted to be active in cytoplasm. Orthologous to human NDRG2 (NDRG family member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Muscle (RPKM 3258.5), Heart (RPKM 3084.1) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p14

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (27074481..27087376, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (24600981..24609621, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (28305820..28314459, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Transformation of A1/A2 Astrocytes Participates in Brain Ischemic Tolerance Induced by Cerebral Ischemic Preconditioning via Inhibiting NDRG2.
Title: Transformation of A1/A2 Astrocytes Participates in Brain Ischemic Tolerance Induced by Cerebral Ischemic Preconditioning via Inhibiting NDRG2.
N-myc downstream regulated gene 2 ameliorates myocardial remodeling and cardiac function in heart failure rats.
Title: N-myc downstream regulated gene 2 ameliorates myocardial remodeling and cardiac function in heart failure rats.
MiR-130a/Ndrg2 Axis Inhibits the Proliferation of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis.
Title: MiR-130a/Ndrg2 Axis Inhibits the Proliferation of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis.
Astrocytic NDRG2 is critical in the maintenance of neuropathic pain.
Title: Astrocytic NDRG2 is critical in the maintenance of neuropathic pain.
Association between NDRG2/IL-6/STAT3 signaling pathway and diabetic retinopathy in rats.
Title: Association between NDRG2/IL-6/STAT3 signaling pathway and diabetic retinopathy in rats.
Relationship between miR-375 regulating Ndrg2/IL-6/STAT3 signaling pathway and diabetic retinopathy in rats.
Title: Relationship between miR-375 regulating Ndrg2/IL-6/STAT3 signaling pathway and diabetic retinopathy in rats.
Increased level of NDRG2 in cortex or hippocampus may be a potential risk for Alzheimer's disease. NDRG2 increased Abeta1-42 might be related to the changes of BEAC1 and GGA3. It might also affect CDK5 and tau overphosphorylation. NDRG2 interacting with STAT3 and modulating Fas/Fasl signaling pathway plays important roles in cell death.
Title: The pathological roles of NDRG2 in Alzheimer's disease, a study using animal models and APPwt-overexpressed cells.
2-arachidonylglycerol protects primary astrocytes exposed to oxygen-glucose deprivation through a blockade of NDRG2 signaling and STAT3 phosphorylation.
Title: 2-Arachidonylglycerol Protects Primary Astrocytes Exposed to Oxygen-Glucose Deprivation Through a Blockade of NDRG2 Signaling and STAT3 Phosphorylation.
Our results demonstrated that NDRG2 promoted secreted miR-375 in microvesicles shed from M1 microglia, which induced neuron damage.
Title: NDRG2 promoted secreted miR-375 in microvesicles shed from M1 microglia, which induced neuron damage.
We further showed that the localized delivery of NDRG2 improved the dysfunction of Na(+) and Cl(-) reabsorption
Title: Retrograde ductal administration of the adenovirus-mediated NDRG2 gene leads to improved sialaden hypofunction in estrogen-deficient rats.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D14S674E (e-PCR)
- UniSTS:151564

RH130102 (e-PCR)
- UniSTS:213390

RH129362 (e-PCR)
- UniSTS:212669

Ndrg2 (e-PCR), detects polymorphism
- UniSTS:507081

RH140915 (e-PCR)
- UniSTS:222929

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytokine production	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of cytokine production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vascular associated smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of vascular associated smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in regulation of platelet-derived growth factor production	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of platelet-derived growth factor production	ISO Inferred from Sequence Orthology more info
involved_in regulation of vascular endothelial growth factor production	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of vascular endothelial growth factor production	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in substantia nigra development	ISO Inferred from Sequence Orthology more info	PubMed
involved_in vascular associated smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of vascular associated smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in growth cone	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein NDRG2

Names: N-myc downstream regulated gene 2; N-myc downstream-regulated gene 2 protein; NDRG1-related protein; antidepressant-related protein ADRG123

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001270862.1 → NP_001257791.1 protein NDRG2 isoform a

See identical proteins and their annotated locations for NP_001257791.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 3 both encode the same isoform (a).

Source sequence(s)

AF334105, FM045410

UniProtKB/Swiss-Prot

Q8VBU2, Q8VBW2, Q8VI00, Q8VI01

UniProtKB/TrEMBL

A0A0G2JSV0, A6KEE6

Related

ENSRNOP00000042949.1, ENSRNOT00000042055.5

Conserved Domains (2) summary

COG0596
Location:119 → 313

MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

pfam03096
Location:40 → 318

Ndr; Ndr family
NM_001270863.1 → NP_001257792.1 protein NDRG2 isoform a

See identical proteins and their annotated locations for NP_001257792.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 both encode the same isoform (a).

Source sequence(s)

AF334105, FM057759

UniProtKB/Swiss-Prot

Q8VBU2, Q8VBW2, Q8VI00, Q8VI01

UniProtKB/TrEMBL

A0A0G2JSV0, A6KEE6

Conserved Domains (2) summary

COG0596
Location:119 → 313

MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

pfam03096
Location:40 → 318

Ndr; Ndr family
NM_001270864.1 → NP_001257793.1 protein NDRG2 isoform b

See identical proteins and their annotated locations for NP_001257793.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2 and 4 both encode the same isoform (b).

Source sequence(s)

AF334106, FM057759

UniProtKB/Swiss-Prot

Q8VBU2, Q8VBW2, Q8VI00, Q8VI01

UniProtKB/TrEMBL

A6KEE4

Related

ENSRNOP00000081522.2, ENSRNOT00000094910.2

Conserved Domains (2) summary

COG0596
Location:105 → 299

MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

pfam03096
Location:26 → 304

Ndr; Ndr family
NM_133583.2 → NP_598267.2 protein NDRG2 isoform b

See identical proteins and their annotated locations for NP_598267.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2 and 4 both encode the same isoform (b).

Source sequence(s)

AF334106, FM045410

UniProtKB/Swiss-Prot

Q8VBU2, Q8VBW2, Q8VI00, Q8VI01

UniProtKB/TrEMBL

A6KEE4

Conserved Domains (2) summary

COG0596
Location:105 → 299

MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

pfam03096
Location:26 → 304

Ndr; Ndr family