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    Hnrnpc heterogeneous nuclear ribonucleoprotein C [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290046, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Hnrnpcprovided by RGD
    Official Full Name
    heterogeneous nuclear ribonucleoprotein Cprovided by RGD
    Primary source
    RGD:1309982
    See related
    EnsemblRapid:ENSRNOG00000011621 AllianceGenome:RGD:1309982
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hnrpc; hnRNP C
    Summary
    Enables several functions, including deaminase binding activity; enzyme inhibitor activity; and ribonucleoprotein complex binding activity. Involved in negative regulation of mRNA modification. Located in nucleoplasmic periphery of the nuclear pore complex. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder. Orthologous to several human genes including HNRNPC (heterogeneous nuclear ribonucleoprotein C). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 442.9), Spleen (RPKM 326.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hnrnpc in Genome Data Viewer
    Location:
    15p14
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (27253098..27282779, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (24779593..24809213, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (28486605..28517353, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102553296 Neighboring gene olfactory receptor family 5 subfamily AU member 1 Neighboring gene RPGR interacting protein 1 Neighboring gene uncharacterized LOC120096964 Neighboring gene SPT16 homolog, facilitates chromatin remodeling subunit Neighboring gene ribosomal protein L9, pseudogene 29

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning of the nucleic acid-binding domain of the rat HnRNP C-type protein. Sharp ZD, et al. Biochim Biophys Acta, 1990 Apr 6. PMID 2088340
    2. Increased expression of cellular RNA-binding proteins in HPV-induced neoplasia and cervical cancer. Fay J, et al. J Med Virol, 2009 May. PMID 19319956
    3. Up-regulation of a hydrogen peroxide-responsive pre-mRNA binding protein in atherosclerosis and intimal hyperplasia. Panchenko MP, et al. Cardiovasc Pathol, 2009 May-Jun. PMID 18508286, Free PMC Article
    4. Inhibition of the apolipoprotein B mRNA editing enzyme-complex by hnRNP C1 protein and 40S hnRNP complexes. Greeve J, et al. Biol Chem, 1998 Aug-Sep. PMID 9792439
    5. The path of RNA through nuclear pores: apparent entry from the sides into specialized pores. Iborra FJ, et al. J Cell Sci, 2000 Jan. PMID 10633080

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC114359

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables N6-methyladenosine-containing RNA reader activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables N6-methyladenosine-containing RNA reader activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables deaminase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables enzyme inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA 3'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables poly(U) RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ribonucleoprotein complex binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables telomerase RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in 3'-UTR-mediated mRNA stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of mRNA modification IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of telomere maintenance via telomerase ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasmic periphery of the nuclear pore complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in pronucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in pronucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of spliceosomal complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of telomerase holoenzyme complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    heterogeneous nuclear ribonucleoprotein C
    Names
    heterogeneous nuclear ribonucleoprotein C (C1/C2)
    heterogeneous nuclear ribonucleoproteins C1/C2
    hnRNP C protein C-terminal fragment (158 AA)
    hnRNP core protein C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277600.1 → NP_001264529.1  heterogeneous nuclear ribonucleoprotein C isoform 1

      See identical proteins and their annotated locations for NP_001264529.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      CB582273, JAXUCZ010000015
      UniProtKB/Swiss-Prot
      D4ACR0, G3V9R8, Q4V8K6
      UniProtKB/TrEMBL
      A6KEG3
      Related
      ENSRNOP00000070427.3, ENSRNOT00000090378.3
      Conserved Domains (1) summary
      cd12603
      Location:10 → 93
      RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)

    2. NM_001277601.1 → NP_001264530.1  heterogeneous nuclear ribonucleoprotein C isoform 2

      See identical proteins and their annotated locations for NP_001264530.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region compared to variant 1. It encodes isoform 2 which is shorter compared to isoform 1.
      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/Swiss-Prot
      D4ACR0, G3V9R8, Q4V8K6
      UniProtKB/TrEMBL
      A0A140TAH9
      Related
      ENSRNOP00000057256.5, ENSRNOT00000060514.5
      Conserved Domains (1) summary
      cd12603
      Location:10 → 93
      RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)

    3. NM_001277602.1 → NP_001264531.1  heterogeneous nuclear ribonucleoprotein C isoform 3

      See identical proteins and their annotated locations for NP_001264531.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses two alternate in-frame splice sites in the coding region compared to variant 1. It encodes isoform 3 which is shorter compared to isoform 1.
      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A0A0G2K7B3, A0A8I6GAF8, A6KEG2
      Conserved Domains (1) summary
      cd12603
      Location:10 → 93
      RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      27253098..27282779 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039093121.2 → XP_038949049.1  heterogeneous nuclear ribonucleoprotein C isoform X4

      UniProtKB/Swiss-Prot
      D4ACR0, G3V9R8, Q4V8K6
      UniProtKB/TrEMBL
      A0A140TAH9
      Conserved Domains (1) summary
      cd12603
      Location:10 → 93
      RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)

    2. XM_039093111.2 → XP_038949039.1  heterogeneous nuclear ribonucleoprotein C isoform X1

      UniProtKB/Swiss-Prot
      D4ACR0, G3V9R8, Q4V8K6
      UniProtKB/TrEMBL
      A6KEG3
      Conserved Domains (1) summary
      cd12603
      Location:10 → 93
      RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)

    3. XM_039093125.2 → XP_038949053.1  heterogeneous nuclear ribonucleoprotein C isoform X6

      UniProtKB/Swiss-Prot
      D4ACR0, G3V9R8, Q4V8K6
      UniProtKB/TrEMBL
      A0A0G2JXW4
      Conserved Domains (1) summary
      cd12603
      Location:10 → 93
      RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)

    4. XM_063274116.1 → XP_063130186.1  heterogeneous nuclear ribonucleoprotein C isoform X6

      UniProtKB/TrEMBL
      A0A0G2JXW4

    5. XM_039093123.2 → XP_038949051.1  heterogeneous nuclear ribonucleoprotein C isoform X5

      UniProtKB/TrEMBL
      A0A0G2K7B3, A0A8I6GAF8, A6KEG2
      Conserved Domains (1) summary
      cd12603
      Location:10 → 93
      RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)

    6. XM_039093119.2 → XP_038949047.1  heterogeneous nuclear ribonucleoprotein C isoform X4

      UniProtKB/Swiss-Prot
      D4ACR0, G3V9R8, Q4V8K6
      UniProtKB/TrEMBL
      A0A140TAH9
      Conserved Domains (1) summary
      cd12603
      Location:10 → 93
      RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)

    7. XM_063274107.1 → XP_063130177.1  heterogeneous nuclear ribonucleoprotein C isoform X3

    8. XM_063274105.1 → XP_063130175.1  heterogeneous nuclear ribonucleoprotein C isoform X2

      UniProtKB/TrEMBL
      A0A8I6G2H2

    9. XM_039093109.2 → XP_038949037.1  heterogeneous nuclear ribonucleoprotein C isoform X1

      UniProtKB/Swiss-Prot
      D4ACR0, G3V9R8, Q4V8K6
      UniProtKB/TrEMBL
      A6KEG3
      Conserved Domains (1) summary
      cd12603
      Location:10 → 93
      RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)

    10. XM_039093113.2 → XP_038949041.1  heterogeneous nuclear ribonucleoprotein C isoform X2

      UniProtKB/TrEMBL
      A0A8I6G2H2, A0A8I6GAF8
      Conserved Domains (1) summary
      cd12603
      Location:10 → 93
      RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)

    11. XM_039093122.2 → XP_038949050.1  heterogeneous nuclear ribonucleoprotein C isoform X5

      UniProtKB/TrEMBL
      A0A0G2K7B3, A0A8I6GAF8, A6KEG2
      Conserved Domains (1) summary
      cd12603
      Location:10 → 93
      RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)

    12. XM_039093115.2 → XP_038949043.1  heterogeneous nuclear ribonucleoprotein C isoform X3

      UniProtKB/Swiss-Prot
      D4ACR0, G3V9R8, Q4V8K6
      Conserved Domains (1) summary
      cd12603
      Location:10 → 93
      RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)

    13. XM_063274117.1 → XP_063130187.1  heterogeneous nuclear ribonucleoprotein C isoform X6

      UniProtKB/TrEMBL
      A0A0G2JXW4

    14. XM_039093116.1 → XP_038949044.1  heterogeneous nuclear ribonucleoprotein C isoform X3

      UniProtKB/Swiss-Prot
      D4ACR0, G3V9R8, Q4V8K6
      Conserved Domains (1) summary
      cd12603
      Location:10 → 93
      RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)

    15. XM_039093114.1 → XP_038949042.1  heterogeneous nuclear ribonucleoprotein C isoform X2

      UniProtKB/TrEMBL
      A0A8I6G2H2, A0A8I6GAF8
      Conserved Domains (1) summary
      cd12603
      Location:10 → 93
      RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)

    16. XM_063274115.1 → XP_063130185.1  heterogeneous nuclear ribonucleoprotein C isoform X6

      UniProtKB/TrEMBL
      A0A0G2JXW4

    17. XM_063274113.1 → XP_063130183.1  heterogeneous nuclear ribonucleoprotein C isoform X5

      UniProtKB/TrEMBL
      A0A0G2K7B3, A6KEG2

    18. XM_039093118.1 → XP_038949046.1  heterogeneous nuclear ribonucleoprotein C isoform X4

      UniProtKB/Swiss-Prot
      D4ACR0, G3V9R8, Q4V8K6
      UniProtKB/TrEMBL
      A0A140TAH9
      Conserved Domains (1) summary
      cd12603
      Location:10 → 93
      RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)

    19. XM_063274104.1 → XP_063130174.1  heterogeneous nuclear ribonucleoprotein C isoform X2

      UniProtKB/TrEMBL
      A0A8I6G2H2

    20. XM_039093108.1 → XP_038949036.1  heterogeneous nuclear ribonucleoprotein C isoform X1

      UniProtKB/Swiss-Prot
      D4ACR0, G3V9R8, Q4V8K6
      UniProtKB/TrEMBL
      A6KEG3
      Conserved Domains (1) summary
      cd12603
      Location:10 → 93
      RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)

    21. XM_063274110.1 → XP_063130180.1  heterogeneous nuclear ribonucleoprotein C isoform X4

      UniProtKB/TrEMBL
      A0A140TAH9

    22. XM_063274111.1 → XP_063130181.1  heterogeneous nuclear ribonucleoprotein C isoform X4

      UniProtKB/TrEMBL
      A0A140TAH9

    23. XM_063274102.1 → XP_063130172.1  heterogeneous nuclear ribonucleoprotein C isoform X1

      UniProtKB/TrEMBL
      A6KEG3

    24. XM_063274108.1 → XP_063130178.1  heterogeneous nuclear ribonucleoprotein C isoform X4

      UniProtKB/TrEMBL
      A0A140TAH9

    25. XM_063274109.1 → XP_063130179.1  heterogeneous nuclear ribonucleoprotein C isoform X4

      UniProtKB/TrEMBL
      A0A140TAH9

    26. XM_063274106.1 → XP_063130176.1  heterogeneous nuclear ribonucleoprotein C isoform X2

      UniProtKB/TrEMBL
      A0A8I6G2H2

    27. XM_063274103.1 → XP_063130173.1  heterogeneous nuclear ribonucleoprotein C isoform X1

      UniProtKB/TrEMBL
      A6KEG3

    28. XM_039093112.2 → XP_038949040.1  heterogeneous nuclear ribonucleoprotein C isoform X1

      UniProtKB/Swiss-Prot
      D4ACR0, G3V9R8, Q4V8K6
      UniProtKB/TrEMBL
      A6KEG3
      Conserved Domains (1) summary
      cd12603
      Location:10 → 93
      RRM_hnRNPC; RNA recognition motif (RRM) found in vertebrate heterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C1/C2)

    29. XM_063274114.1 → XP_063130184.1  heterogeneous nuclear ribonucleoprotein C isoform X5

      UniProtKB/TrEMBL
      A0A0G2K7B3, A6KEG2
      Related
      ENSRNOP00000074135.2, ENSRNOT00000086177.3

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001025633.1: Suppressed sequence

      Description
      NM_001025633.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G3V9R8.2 GenPept UniProtKB/Swiss-Prot:G3V9R8

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