Impa1 inositol monophosphatase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Impa1provided by RGD
Official Full Name: inositol monophosphatase 1provided by RGD
Primary source: RGD:69254
See related: EnsemblRapid:ENSRNOG00000010482 AllianceGenome:RGD:69254
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Impa1-L
Summary: Enables inositol monophosphate 1-phosphatase activity and metal ion binding activity. Involved in phosphatidylinositol biosynthetic process. Located in axon and neuronal cell body. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 59 and intellectual disability. Orthologous to human IMPA1 (inositol monophosphatase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 247.8), Kidney (RPKM 227.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q23

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (93370200..93391474)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (91462781..91484057)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (93675203..93696355)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cytoplasmic cleavage of IMPA1 3' UTR is necessary for maintaining axon integrity.
Title: Cytoplasmic cleavage of IMPA1 3' UTR is necessary for maintaining axon integrity.
Diminished Myoinositol in Ventromedial Prefrontal Cortex Modulates the Endophenotype of Impulsivity.
Title: Diminished Myoinositol in Ventromedial Prefrontal Cortex Modulates the Endophenotype of Impulsivity.
conclude that the formation of the newly discovered RAGE-IMPA1 complex could be responsible for the stimulation of inositol pathways and activation of Akt signaling in pulmonary arterial hypertension
Title: Inositol monophosphatase 1 as a novel interacting partner of RAGE in pulmonary hypertension.
local synthesis of IMPA1 is required for neurotrophin-dependent axon growth; selective regulation of IMPA1 levels in axons may provide a target for the development of new therapeutic strategies for specific neurological and psychiatric diseases
Title: An NGF-responsive element targets myo-inositol monophosphatase-1 mRNA to sympathetic neuron axons.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables inositol monophosphate 1-phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables inositol monophosphate 1-phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables inositol monophosphate 1-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables inositol monophosphate 1-phosphatase activity	ISO Inferred from Sequence Orthology more info
enables inositol monophosphate phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables inositol monophosphate phosphatase activity	ISO Inferred from Sequence Orthology more info
enables lithium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables lithium ion binding	IEA Inferred from Electronic Annotation more info
enables lithium ion binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables manganese ion binding	IDA Inferred from Direct Assay more info	PubMed
enables manganese ion binding	IEA Inferred from Electronic Annotation more info
enables manganese ion binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in inositol biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in inositol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphate-containing compound metabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylinositol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: inositol monophosphatase 1

Names: D-galactose 1-phosphate phosphatase; IMP 1; IMPase 1; Inositol (myo)-1(or 4)-monophosphatase 1; inositol-1(or 4)-monophosphatase 1; lithium-sensitive myo-inositol monophosphatase A1

NP_114446.2

EC 3.1.3.25

EC 3.1.3.94

XP_006232213.1

EC 3.1.3.25

EC 3.1.3.94

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_032057.2 → NP_114446.2 inositol monophosphatase 1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

P97697

Related

ENSRNOP00000110780.1, ENSRNOT00000132949.1

Conserved Domains (1) summary

cd01639
Location:8 → 254

IMPase; inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be recycled ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

93370200..93391474

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006232151.5 → XP_006232213.1 inositol monophosphatase 1 isoform X1

UniProtKB/Swiss-Prot

P97697

UniProtKB/TrEMBL

F1M978

Related

ENSRNOP00000014274.4, ENSRNOT00000014274.6

Conserved Domains (1) summary

cd01639
Location:61 → 307

IMPase; IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be ...