SEC61 translocon subunit SEC61 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SEC61
Official Full Name: translocon subunit SEC61
Primary source: SGD:S000004370
Locus tag: YLR378C
See related: AllianceGenome:SGD:S000004370; FungiDB:YLR378C; VEuPathDB:YLR378C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables peptide transmembrane transporter activity; protein-transporting ATPase activity; and signal sequence binding activity. Involved in intracellular protein transport. Located in endoplasmic reticulum. Part of Sec61 translocon complex. Human ortholog(s) of this gene implicated in common variable immunodeficiency; familial juvenile hyperuricemic nephropathy; and severe congenital neutropenia. Orthologous to human SEC61A1 (SEC61 translocon subunit alpha 1) and SEC61A2 (SEC61 translocon subunit alpha 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See SEC61 in Genome Data Viewer

Location:: chromosome: XII

Exon count:: 1

Sequence:: Chromosome: XII; NC_001144.5 (875736..877178, complement)

Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Characterization of the interaction between the Sec61 translocon complex and ppalphaF using optical tweezers.
Title: Characterization of the interaction between the Sec61 translocon complex and ppαF using optical tweezers.
Sec61 channel subunit Sbh1/Sec61beta promotes ER translocation of proteins with suboptimal targeting sequences and is fine-tuned by phosphorylation.
Title: Sec61 channel subunit Sbh1/Sec61β promotes ER translocation of proteins with suboptimal targeting sequences and is fine-tuned by phosphorylation.
Effect of Sec62 on the conformation of the Sec61 channel in yeast.
Title: Effect of Sec62 on the conformation of the Sec61 channel in yeast.
Cancer associated mutations in Sec61gamma alter the permeability of the ER translocase.
Title: Cancer associated mutations in Sec61γ alter the permeability of the ER translocase.
Stepwise gating of the Sec61 protein-conducting channel by Sec63 and Sec62.
Title: Stepwise gating of the Sec61 protein-conducting channel by Sec63 and Sec62.
The conserved C-terminus of Sss1p is required to maintain the endoplasmic reticulum permeability barrier.
Title: The conserved C-terminus of Sss1p is required to maintain the endoplasmic reticulum permeability barrier.
data suggest that Mpd1 binding to Sec61 is a prerequisite for CPY* ERAD and confirm a role of Sec61 in ERAD of misfolded secretory proteins.
Title: Effect of Sec61 interaction with Mpd1 on endoplasmic reticulum-associated degradation.
Sec63 tightly associates with Sec61 through interactions in cytosolic, transmembrane, and endoplasmic reticulum -luminal domains, prying open Sec61's lateral gate and translocation pore and thus activating the channel for substrate engagement.
Title: Structure of the posttranslational Sec protein-translocation channel complex from yeast.
Substitutions replacing basic residues with acidic residues in the C-terminal tail of Sec61 had an unanticipated impact upon binding of ribosomes to the Sec61 complex. The results have identified additional cytosolic segments of the Sec61 complex important for promoting the structural transition between the closed and open conformations of the complex.
Title: Conserved motifs on the cytoplasmic face of the protein translocation channel are critical for the transition between resting and active conformations.
Increased endoplasmic reticulum glutathione import triggers H2O2-dependent Bip oxidation through Ero1 reductive activation, which inhibits glutathione import in a negative regulatory loop.
Title: Endoplasmic Reticulum Transport of Glutathione by Sec61 Is Regulated by Ero1 and Bip.

Submit: New GeneRIF Correction See all GeneRIFs (27)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables peptide transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-transporting ATPase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-transporting ATPase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ribosome binding	IBA Inferred from Biological aspect of Ancestor more info
enables signal sequence binding	IBA Inferred from Biological aspect of Ancestor more info
enables signal sequence binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in ERAD pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ERAD pathway	IPI Inferred from Physical Interaction more info	PubMed
involved_in SRP-dependent cotranslational protein targeting to membrane, translocation	IBA Inferred from Biological aspect of Ancestor more info
involved_in SRP-dependent cotranslational protein targeting to membrane, translocation	IDA Inferred from Direct Assay more info	PubMed
involved_in establishment of protein localization	IEA Inferred from Electronic Annotation more info
involved_in misfolded protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in post-translational protein targeting to membrane, translocation	IBA Inferred from Biological aspect of Ancestor more info
involved_in post-translational protein targeting to membrane, translocation	IDA Inferred from Direct Assay more info	PubMed
involved_in post-translational protein targeting to membrane, translocation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in retrograde protein transport, ER to cytosol	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Sec61 translocon complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Sec61 translocon complex	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	HDA more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: translocon subunit SEC61

NP_013482.1

Conserved ER protein translocation channel; essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms channel for SRP-dependent protein import; with Sec63 complex is required for SRP-independent protein translocation into the ER; involved in posttranslational soluble protein import into the ER, ERAD of soluble substrates, and misfolded soluble protein export from the ER