Aldob aldolase, fructose-bisphosphate B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Aldobprovided by RGD
Official Full Name: aldolase, fructose-bisphosphate Bprovided by RGD
Primary source: RGD:2090
See related: EnsemblRapid:ENSRNOG00000006807 AllianceGenome:RGD:2090
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Aldo2; LIV10
Summary: Enables fructose-bisphosphate aldolase activity and phosphatidylcholine binding activity. Involved in several processes, including cellular response to insulin stimulus; response to fructose; and response to interleukin-6. Located in perinuclear region of cytoplasm; rough endoplasmic reticulum membrane; and smooth endoplasmic reticulum membrane. Used to study type 2 diabetes mellitus. Biomarker of liver benign neoplasm; peritonitis; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in hereditary fructose intolerance syndrome and type 2 diabetes mellitus. Orthologous to human ALDOB (aldolase, fructose-bisphosphate B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 18877.2) and Liver (RPKM 14191.4) See more
Orthologs: human mouse all
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Genomic context

Location:: 5q22

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (68684541..68697582, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (63889045..63902086, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (64805772..64818813, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest energy metabolism (gluconeogenesis versus glycolysis) modulates aldolase B and fructose-1,6-bisphosphatase-1 activities in hepatocytes via their interaction suggesting their association confers catalytic advantage for both enzymes.
Title: A new level of regulation in gluconeogenesis: metabolic state modulates the intracellular localization of aldolase B and its interaction with liver fructose-1,6-bisphosphatase.
Upregulation of aldolase B by accumulated fructose is a common mechanism for methylglyoxal overproduction in vascular smooth muscle cella and aorta in different models of metabolic syndrome.
Title: Upregulation of aldolase B and overproduction of methylglyoxal in vascular tissues from rats with metabolic syndrome.
Data indicate the presence of a modulated interaction between fructose-1,6-bisphosphatase and aldolase B, and suggest that in kidney, aldolase B specifically participates in gluconeogenesis and with aldolase A in glycolysis.
Title: Different involvement for aldolase isoenzymes in kidney glucose metabolism: aldolase B but not aldolase A colocalizes and forms a complex with FBPase.
Binding of ALF-C enhances replicator activity of Aldob.
Title: Binding of AlF-C, an Orc1-binding transcriptional regulator, enhances replicator activity of the rat aldolase B origin.

Submit: New GeneRIF Correction

General gene information

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Markers

RH129202 (e-PCR)
- UniSTS:212510

RH94455 (e-PCR)
- UniSTS:119703

RH129135 (e-PCR)
- UniSTS:212443

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATPase binding	IEA Inferred from Electronic Annotation more info
enables ATPase binding	ISO Inferred from Sequence Orthology more info
enables cytoskeletal protein binding	IEA Inferred from Electronic Annotation more info
enables cytoskeletal protein binding	ISO Inferred from Sequence Orthology more info
enables fructose binding	IEA Inferred from Electronic Annotation more info
enables fructose binding	ISO Inferred from Sequence Orthology more info
enables fructose-1-phosphate aldolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables fructose-1-phosphate aldolase activity	IEA Inferred from Electronic Annotation more info
enables fructose-1-phosphate aldolase activity	ISO Inferred from Sequence Orthology more info
enables fructose-1-phosphate aldolase activity	ISS Inferred from Sequence or Structural Similarity more info
enables fructose-bisphosphate aldolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables fructose-bisphosphate aldolase activity	IDA Inferred from Direct Assay more info	PubMed
enables fructose-bisphosphate aldolase activity	IEA Inferred from Electronic Annotation more info
enables fructose-bisphosphate aldolase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	IEA Inferred from Electronic Annotation more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylcholine binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in NADH oxidation	IEA Inferred from Electronic Annotation more info
involved_in NADH oxidation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to insulin stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in fructose 1,6-bisphosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fructose 1,6-bisphosphate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in fructose 1,6-bisphosphate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in fructose catabolic process	ISO Inferred from Sequence Orthology more info
involved_in fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate	IEA Inferred from Electronic Annotation more info
involved_in fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate	ISO Inferred from Sequence Orthology more info
involved_in fructose metabolic process	ISO Inferred from Sequence Orthology more info
involved_in gluconeogenesis	IEA Inferred from Electronic Annotation more info
involved_in glycolytic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycolytic process	IEA Inferred from Electronic Annotation more info
involved_in glycolytic process	ISO Inferred from Sequence Orthology more info
involved_in glycolytic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in liver development	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of pentose-phosphate shunt	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of pentose-phosphate shunt	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ATP-dependent activity	ISO Inferred from Sequence Orthology more info
involved_in response to amino acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cAMP	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to carbohydrate	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to copper ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to fructose	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucocorticoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to interleukin-6	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to peptide hormone	IDA Inferred from Direct Assay more info	PubMed
involved_in response to starvation	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to zinc ion	IDA Inferred from Direct Assay more info	PubMed
involved_in vacuolar proton-transporting V-type ATPase complex assembly	IEA Inferred from Electronic Annotation more info
involved_in vacuolar proton-transporting V-type ATPase complex assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in centriolar satellite	IEA Inferred from Electronic Annotation more info
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in microtubule organizing center	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in rough endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in smooth endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: fructose-bisphosphate aldolase B

Names: Aldolase B, fructose-biphosphate; aldolase B, fructose-bisphosphate; liver-type aldolase

NP_036628.2

EC 4.1.2.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.