CEF1 Cef1p [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: CEF1
Official Full Name: Cef1p
Primary source: SGD:S000004826
Locus tag: YMR213W
See related: AllianceGenome:SGD:S000004826; FungiDB:YMR213W; VEuPathDB:YMR213W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: NTC85
Summary: Contributes to second spliceosomal transesterification activity. Involved in generation of catalytic spliceosome for second transesterification step. Part of Prp19 complex and U2-type catalytic step 1 spliceosome. Human ortholog(s) of this gene implicated in osteosarcoma. Orthologous to human CDC5L (cell division cycle 5 like). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
contributes_to second spliceosomal transesterification activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in generation of catalytic spliceosome for second transesterification step	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA splicing, via spliceosome	IEA Inferred from Electronic Annotation more info
involved_in mRNA splicing, via spliceosome	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Prp19 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Prp19 complex	IDA Inferred from Direct Assay more info	PubMed
part_of Prp19 complex	IEA Inferred from Electronic Annotation more info
part_of U2-type catalytic step 1 spliceosome	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of spliceosomal complex	IBA Inferred from Biological aspect of Ancestor more info
part_of spliceosomal complex	IEA Inferred from Electronic Annotation more info

NP_013940.1

Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p

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The following sections contain reference sequences that belong to a specific genome build. Explain