Naa15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Naa15provided by RGD
Official Full Name: N(alpha)-acetyltransferase 15, NatA auxiliary subunitprovided by RGD
Primary source: RGD:1310984
See related: EnsemblRapid:ENSRNOG00000012385 AllianceGenome:RGD:1310984
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Narg1
Summary: Predicted to enable N-acetyltransferase activity and acetyltransferase activator activity. Predicted to contribute to acetyltransferase activity and ribosome binding activity. Predicted to be involved in several processes, including N-terminal protein amino acid acetylation; positive regulation of DNA-templated transcription; and protein stabilization. Predicted to be located in cytosol and nuclear body. Predicted to be part of NatA complex and transcription regulator complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 50. Orthologous to human NAA15 (N-alpha-acetyltransferase 15, NatA auxiliary subunit). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Muscle (RPKM 210.2), Heart (RPKM 190.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q26

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (137608883..137671618)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (135458018..135520756)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (140471437..140534259)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

MARC_15315-15316:1013436374:1 (e-PCR)
- UniSTS:267809

RH133610 (e-PCR)
- UniSTS:216893

RH138227 (e-PCR)
- UniSTS:220314

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables N-acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables acetyltransferase activator activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to acetyltransferase activity	ISO Inferred from Sequence Orthology more info
contributes_to ribosome binding	ISO Inferred from Sequence Orthology more info
enables ribosome binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in N-terminal protein amino acid acetylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of NatA complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NatA complex	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: N-alpha-acetyltransferase 15, NatA auxiliary subunit

Names: NMDA receptor regulated 1; NMDA receptor-regulated gene 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107674.1 → NP_001101144.1 N-alpha-acetyltransferase 15, NatA auxiliary subunit

See identical proteins and their annotated locations for NP_001101144.1

Status: PROVISIONAL

Source sequence(s)

CH474003

UniProtKB/TrEMBL

A0A8I6A145, A6JV67, D3ZD89

Related

ENSRNOP00000017379.6, ENSRNOT00000017379.8

Conserved Domains (3) summary

sd00006
Location:82 → 108

TPR; TPR repeat [structural motif]

pfam12569
Location:187 → 698

NARP1; NMDA receptor-regulated protein 1

pfam13414
Location:82 → 145

TPR_11; TPR repeat