Pcsk6 proprotein convertase subtilisin/kexin type 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pcsk6provided by RGD
Official Full Name: proprotein convertase subtilisin/kexin type 6provided by RGD
Primary source: RGD:3246
See related: EnsemblRapid:ENSRNOG00000011526 AllianceGenome:RGD:3246
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Spc4; Pace4
Summary: Predicted to enable heparin binding activity; nerve growth factor binding activity; and serine-type endopeptidase activity. Involved in peptide hormone processing. Predicted to be active in several cellular components, including cell surface; collagen-containing extracellular matrix; and extracellular space. Orthologous to human PCSK6 (proprotein convertase subtilisin/kexin type 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 199.7), Liver (RPKM 95.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q22

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (128839742..129038087)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (119428978..119627626)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (126749508..126947392)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PCSK6 knockdown significantly decreased the cell proliferation, invasion and migration of fibroblastlike synoviocytes from rats with collageninduced arthritis.
Title: Inhibition of pro-protein convertase subtilisin/kexin type 6 has a protective role against synovitis in a rat model of rheumatoid arthritis.
PACE4 regulates the SMG development via the activation of some growth/differentiation factors.
Title: Inhibition and transcriptional silencing of a subtilisin-like proprotein convertase, PACE4/SPC4, reduces the branching morphogenesis of and AQP5 expression in rat embryonic submandibular gland.
temporospatially regulated expression of PACE4 suggests its apparent association with the proliferation, differentiation, and establishment of functional acinar and ductal cells of the submandibular gland.
Title: Temporospatially regulated expression of subtilisin-like proprotein convertase PACE4 (SPC4) during development of the rat submandibular gland.
Selective and transient association of RCN-3 with the precursor of PACE4 plays an important role in the biosynthesis of PACE4.
Title: A proteomic approach reveals transient association of reticulocalbin-3, a novel member of the CREC family, with the precursor of subtilisin-like proprotein convertase, PACE4.

Submit: New GeneRIF Correction

General gene information

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Markers

Pcsk6 (e-PCR), detects polymorphism
- UniSTS:532494

RH36675 (e-PCR)
- UniSTS:92956

BI275853 (e-PCR)
- UniSTS:249656

D1Bda24 (e-PCR)
- UniSTS:239771

D50060 (e-PCR)
- UniSTS:124837

RH129145 (e-PCR)
- UniSTS:212453

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables heparin binding	ISO Inferred from Sequence Orthology more info
enables nerve growth factor binding	IEA Inferred from Electronic Annotation more info
enables nerve growth factor binding	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in determination of left/right symmetry	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within determination of left/right symmetry	ISO Inferred from Sequence Orthology more info
involved_in glycoprotein metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycoprotein metabolic process	ISO Inferred from Sequence Orthology more info
involved_in nerve growth factor production	IEA Inferred from Electronic Annotation more info
involved_in nerve growth factor production	ISO Inferred from Sequence Orthology more info
involved_in peptide hormone processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptide hormone processing	IEA Inferred from Electronic Annotation more info
involved_in peptide hormone processing	IEP Inferred from Expression Pattern more info	PubMed
involved_in peptide hormone processing	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein processing	ISO Inferred from Sequence Orthology more info
involved_in protein processing	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in secretion by cell	IEA Inferred from Electronic Annotation more info
involved_in secretion by cell	ISO Inferred from Sequence Orthology more info
involved_in zygotic determination of anterior/posterior axis, embryo	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within zygotic determination of anterior/posterior axis, embryo	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in collagen-containing extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in collagen-containing extracellular matrix	IEA Inferred from Electronic Annotation more info
located_in collagen-containing extracellular matrix	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: proprotein convertase subtilisin/kexin type 6

Names: Subtilisin - like endoprotease; kexin-like protease PC7A; paired basic amino acid cleaving enzyme 4; subtilisin-like proprotein convertase 4; subtilisin/kexin-like protease PACE4

NP_037131.2

EC 3.4.21.-

XP_038957724.1

EC 3.4.21.-

XP_038957726.1

EC 3.4.21.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012999.2 → NP_037131.2 proprotein convertase subtilisin/kexin type 6 precursor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

Q63415

UniProtKB/TrEMBL

F1LNB4

Related

ENSRNOP00000015845.9, ENSRNOT00000015845.9

Conserved Domains (7) summary

cd04059
Location:141 → 435

Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases

smart00261
Location:812 → 854

FU; Furin-like repeats

cd00064
Location:768 → 813

FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.

pfam01483
Location:520 → 610

P_proprotein; Proprotein convertase P-domain

pfam08686
Location:910 → 933

PLAC; PLAC (protease and lacunin) domain

pfam14843
Location:662 → 772

GF_recep_IV; Growth factor receptor domain IV

pfam16470
Location:56 → 132

S8_pro-domain; Peptidase S8 pro-domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

128839742..129038087

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039101796.2 → XP_038957724.1 proprotein convertase subtilisin/kexin type 6 isoform X1

UniProtKB/Swiss-Prot

Q63415

UniProtKB/TrEMBL

A0A8I5ZLS8

Related

ENSRNOP00000078906.2, ENSRNOT00000106454.2

Conserved Domains (7) summary

cd04059
Location:141 → 435

Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases

smart00261
Location:825 → 867

FU; Furin-like repeats

cd00064
Location:781 → 826

FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.

pfam01483
Location:520 → 610

P_proprotein; Proprotein convertase P-domain

pfam08686
Location:923 → 946

PLAC; PLAC (protease and lacunin) domain

pfam14843
Location:675 → 785

GF_recep_IV; Growth factor receptor domain IV

pfam16470
Location:56 → 132

S8_pro-domain; Peptidase S8 pro-domain
XM_039101798.2 → XP_038957726.1 proprotein convertase subtilisin/kexin type 6 isoform X2

UniProtKB/TrEMBL

A6JBN6

Conserved Domains (6) summary

cd04059
Location:2 → 215

Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases

smart00261
Location:605 → 647

FU; Furin-like repeats

cd00064
Location:561 → 606

FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.

pfam01483
Location:300 → 390

P_proprotein; Proprotein convertase P-domain

pfam08686
Location:703 → 726

PLAC; PLAC (protease and lacunin) domain

pfam14843
Location:455 → 565

GF_recep_IV; Growth factor receptor domain IV