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    STB1 Stb1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855407, updated on 9-Dec-2024

    Summary

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    Official Symbol
    STB1
    Official Full Name
    Stb1p
    Primary source
    SGD:S000005253
    Locus tag
    YNL309W
    See related
    AllianceGenome:SGD:S000005253; FungiDB:YNL309W; VEuPathDB:YNL309W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables transcription coactivator activity. Involved in G1/S transition of mitotic cell cycle; positive regulation of mating type switching; and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Part of MBF transcription complex; SBF transcription complex; and Sin3-type complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See STB1 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (52662..53924)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene putative SCF ubiquitin ligase complex subunit SKP2 Neighboring gene Zim17p Neighboring gene Kri1p Neighboring gene serine/threonine/tyrosine protein kinase MCK1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Interactions, structural aspects and evolutionary perspectives of the yeast 'START'-regulatory network. Stephan OOH. FEMS Yeast Res, 2022 Jan 28. PMID 34905017
    2. A large protein complex containing the yeast Sin3p and Rpd3p transcriptional regulators. Kasten MM, et al. Mol Cell Biol, 1997 Aug. PMID 9234741, Free PMC Article
    3. The cell-cycle transcriptional network generates and transmits a pulse of transcription once each cell cycle. Cho CY, et al. Cell Cycle, 2019 Feb. PMID 30668223, Free PMC Article
    4. Competition in the chaperone-client network subordinates cell-cycle entry to growth and stress. Moreno DF, et al. Life Sci Alliance, 2019 Apr. PMID 30988162, Free PMC Article
    5. G1 transcription factors are differentially regulated in Saccharomyces cerevisiae by the Swi6-binding protein Stb1. Costanzo M, et al. Mol Cell Biol, 2003 Jul. PMID 12832490, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Interactions, structural aspects and evolutionary perspectives of the yeast 'START'-regulatory network.
      Title: Interactions, structural aspects and evolutionary perspectives of the yeast 'START'-regulatory network.
    2. Cln3 regulates SBF by at least two different pathways, one involving the repressive protein Whi5, and the second involving Stb1.
      Title: Recruitment of Cln3 cyclin to promoters controls cell cycle entry via histone deacetylase and other targets.
    3. Chromatin immunoprecipitation experiments show that SBF, Whi5 and Stb1 recruit both Cdc28 and the Rpd3(L) histone deacetylase to G1 cyclin promoters.
      Title: The E2F functional analogue SBF recruits the Rpd3(L) HDAC, via Whi5 and Stb1, and the FACT chromatin reorganizer, to yeast G1 cyclin promoters.
    4. Results show that Stb1 is a stable component of both SBF and MBF that binds G(1)-specific promoters via Swi6 during G(1) phase.
      Title: Stb1 collaborates with other regulators to modulate the G1-specific transcriptional circuit.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables transcription coactivator activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mating type switching IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MBF transcription complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SBF transcription complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Sin3-type complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Sin3-type complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Stb1p
    NP_014090.2
    • Protein with role in regulation of MBF-specific transcription at Start; phosphorylated by Cln-Cdc28p kinases in vitro; unphosphorylated form binds Swi6p, which is required for Stb1p function; expression is cell-cycle regulated; STB1 has a paralog, YOL131W, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      52662..53924
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183147.1 → NP_014090.2  TPA: Stb1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014090.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0N6, P42845
      UniProtKB/TrEMBL
      A6ZSH1, C8ZGL5, G2WLG0, N1NXX7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P42845.2

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