U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    SKP2 putative SCF ubiquitin ligase complex subunit SKP2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855405, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    SKP2
    Official Full Name
    putative SCF ubiquitin ligase complex subunit SKP2
    Primary source
    SGD:S000005255
    Locus tag
    YNL311C
    See related
    AllianceGenome:SGD:S000005255; FungiDB:YNL311C; VEuPathDB:YNL311C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable protein-macromolecule adaptor activity. Involved in protein catabolic process and regulation of sulfur amino acid metabolic process. Part of SCF ubiquitin ligase complex. [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See SKP2 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (49397..51688, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat-containing protein EMW1 Neighboring gene Rfa2p Neighboring gene Zim17p Neighboring gene Stb1p

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Identification of new Saccharomyces cerevisiae variants of the MET2 and SKP2 genes controlling the sulfur assimilation pathway and the production of undesirable sulfur compounds during alcoholic fermentation. Noble J, et al. Microb Cell Fact, 2015 May 8. PMID 25947166, Free PMC Article
    2. Developing structure-activity relationships from an HTS hit for inhibition of the Cks1-Skp2 protein-protein interaction. Singh R, et al. Bioorg Med Chem Lett, 2015 Nov 15. PMID 26463131
    3. Identification of F-box proteins that are involved in resistance to methylmercury in Saccharomyces cerevisiae. Hwang GW, et al. FEBS Lett, 2006 Dec 22. PMID 17141224
    4. Combinatorial control in ubiquitin-dependent proteolysis: don't Skp the F-box hypothesis. Patton EE, et al. Trends Genet, 1998 Jun. PMID 9635407
    5. A novel mechanism regulates H(2) S and SO(2) production in Saccharomyces cerevisiae. Yoshida S, et al. Yeast, 2011 Feb. PMID 20936605

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein-macromolecule adaptor activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of sulfur amino acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SCF ubiquitin ligase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    putative SCF ubiquitin ligase complex subunit SKP2
    NP_014088.1
    • F-box hypothetical protein; predicted to be part of an SCF ubiquitin protease complex; involved in regulating protein levels of sulfur metabolism enzymes; may interact with ribosomes, based on co-purification experiments

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      49397..51688 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183149.1 → NP_014088.1  TPA: putative SCF ubiquitin ligase complex subunit SKP2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014088.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0N4, P42843, Q6B2L9
      UniProtKB/TrEMBL
      C7GWQ8, G2WLF8, N1NXF4
      Conserved Domains (1) summary
      pfam12937
      Location:60 → 100
      F-box-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P42843.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools