U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Syt6 synaptotagmin 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 60565, updated on 27-Nov-2024

    Summary

    Official Symbol
    Syt6provided by RGD
    Official Full Name
    synaptotagmin 6provided by RGD
    Primary source
    RGD:62012
    See related
    EnsemblRapid:ENSRNOG00000019163 AllianceGenome:RGD:62012
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables syntaxin binding activity. Involved in postsynaptic dense core vesicle exocytosis. Is active in glutamatergic synapse and synaptic membrane. Orthologous to human SYT6 (synaptotagmin 6). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 283.0) and Brain (RPKM 42.4) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Syt6 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (193781051..193840741)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (191093009..191152283)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (206064181..206119034)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene ribosomal biogenesis factor like 2 Neighboring gene uncharacterized LOC134485943 Neighboring gene uncharacterized LOC120100901 Neighboring gene uncharacterized LOC102546891 Neighboring gene small nucleolar RNA U13 Neighboring gene uncharacterized LOC134485944

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC116356

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium ion sensor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium-dependent phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    NOT enables calcium-dependent phospholipid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium-dependent phospholipid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables clathrin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables clathrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylserine binding ISO
    Inferred from Sequence Orthology
    more info
     
    NOT enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    NOT enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables syntaxin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables syntaxin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables syntaxin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in acrosomal vesicle exocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in acrosomal vesicle exocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in acrosome reaction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in postsynaptic dense core vesicle exocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in postsynaptic dense core vesicle exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of calcium ion-dependent exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic side of plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in exocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in synaptic membrane EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in synaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synaptic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    synaptotagmin-6
    Names
    synaptotagmin VI
    sytVI

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022191.3NP_071527.1  synaptotagmin-6

      See identical proteins and their annotated locations for NP_071527.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      Q4KLI6, Q62746
      UniProtKB/TrEMBL
      A0A8I6ABK1, A6K3L5
      Related
      ENSRNOP00000025953.7, ENSRNOT00000025953.7
      Conserved Domains (2) summary
      cd08385
      Location:231355
      C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
      cd08403
      Location:364497
      C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      193781051..193840741
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039103020.2XP_038958948.1  synaptotagmin-6 isoform X1

      UniProtKB/TrEMBL
      A0A8L2QEQ5
      Related
      ENSRNOP00000081725.2, ENSRNOT00000094540.2
      Conserved Domains (2) summary
      cd08385
      Location:231355
      C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
      cd08403
      Location:364497
      C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10
    2. XM_039103022.2XP_038958950.1  synaptotagmin-6 isoform X3

      UniProtKB/TrEMBL
      A0A8L2QEQ5
      Conserved Domains (2) summary
      cd08385
      Location:146270
      C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
      cd08403
      Location:279412
      C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10
    3. XM_063282441.1XP_063138511.1  synaptotagmin-6 isoform X4

      UniProtKB/TrEMBL
      A0A0G2JW68
    4. XM_039103023.2XP_038958951.1  synaptotagmin-6 isoform X3

      UniProtKB/TrEMBL
      A0A8L2QEQ5
      Conserved Domains (2) summary
      cd08385
      Location:146270
      C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
      cd08403
      Location:279412
      C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10
    5. XM_039103021.2XP_038958949.1  synaptotagmin-6 isoform X2

      UniProtKB/TrEMBL
      A0A8I6ABK1
      Conserved Domains (2) summary
      cd08385
      Location:237361
      C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
      cd08403
      Location:370503
      C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10

    RNA

    1. XR_005500359.2 RNA Sequence

    2. XR_005500358.2 RNA Sequence