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    PDR10 ATP-binding cassette multidrug transporter PDR10 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854506, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PDR10
    Official Full Name
    ATP-binding cassette multidrug transporter PDR10
    Primary source
    SGD:S000005855
    Locus tag
    YOR328W
    See related
    AllianceGenome:SGD:S000005855; FungiDB:YOR328W; VEuPathDB:YOR328W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable ATPase-coupled transmembrane transporter activity. Involved in replication-born double-strand break repair via sister chromatid exchange. Located in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PDR10 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (931803..936497)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene myosin 2 Neighboring gene SNAP receptor SNC2 Neighboring gene Scd5p Neighboring gene DNA-directed DNA polymerase gamma MIP1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Construction of reporter gene assays using CWP and PDR mutant yeasts for enhanced detection of various sex steroids. Ito-Harashima S, et al. Genes Environ, 2020. PMID 32514322, Free PMC Article
    2. The yeast ATP binding cassette (ABC) protein genes PDR10 and PDR15 are novel targets for the Pdr1 and Pdr3 transcriptional regulators. Wolfger H, et al. FEBS Lett, 1997 Dec 1. PMID 9428726
    3. Hypervariable noncoding sequences in Saccharomyces cerevisiae. Fay JC, et al. Genetics, 2005 Aug. PMID 15956668, Free PMC Article
    4. Engineering endogenous ABC transporter with improving ATP supply and membrane flexibility enhances the secretion of β-carotene in Saccharomyces cerevisiae. Bu X, et al. Biotechnol Biofuels, 2020. PMID 33062054, Free PMC Article
    5. ATPase and multidrug transport activities of the overexpressed yeast ABC protein Yor1p. Decottignies A, et al. J Biol Chem, 1998 May 15. PMID 9575223

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in replication-born double-strand break repair via sister chromatid exchange IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in xenobiotic detoxification by transmembrane export across the plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in xenobiotic detoxification by transmembrane export across the plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in fungal-type vacuole HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ATP-binding cassette multidrug transporter PDR10
    NP_014973.1
    • ATP-binding cassette (ABC) transporter; multidrug transporter involved in the pleiotropic drug resistance network; regulated by Pdr1p and Pdr3p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      931803..936497
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183748.1 → NP_014973.1  TPA: ATP-binding cassette multidrug transporter PDR10 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014973.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W325, P51533
      UniProtKB/TrEMBL
      B3LJY9, C7GNT6, C8ZH79, N1NX10
      Conserved Domains (1) summary
      TIGR00956
      Location:110 → 1556
      3a01205; Pleiotropic Drug Resistance (PDR) Family protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P51533.1

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