OXR1 Oxr1p [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: OXR1
Official Full Name: Oxr1p
Primary source: SGD:S000006117
Locus tag: YPL196W
See related: AllianceGenome:SGD:S000006117; FungiDB:YPL196W; VEuPathDB:YPL196W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Acts upstream of or within protein retention in Golgi apparatus; protein-containing complex disassembly; and regulation of proton-transporting ATPase activity, rotational mechanism. Located in mitochondrion. Orthologous to human TLDC2 (TBC/LysM-associated domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

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Molecular mechanism of Oxr1p mediated disassembly of yeast V-ATPase.
Title: Molecular mechanism of Oxr1p mediated disassembly of yeast V-ATPase.
Oxidative stress protein Oxr1 promotes V-ATPase holoenzyme disassembly in catalytic activity-independent manner.
Title: Oxidative stress protein Oxr1 promotes V-ATPase holoenzyme disassembly in catalytic activity-independent manner.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within protein retention in Golgi apparatus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein-containing complex disassembly	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein-containing complex disassembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of proton-transporting ATPase activity, rotational mechanism	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of proton-transporting ATPase activity, rotational mechanism	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oxidative stress	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

NP_015128.1

Protein that regulates the vacuolar V-ATPase; inhibits V1-ATPase activity and triggers ATP-dependent disassembly of the V-ATPase holoenzyme, counteracting the function of the RAVE complex; localizes to the cytoplasm; required for retention of the vacuolar-ATPase V0 domain subunit Stv1p in pre-vacuolar compartments; involved in resistance to oxidative damage; member of a conserved family of TLDc domain proteins found in eukaryotes; contains an N-terminal EF-hand-like domain

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The following sections contain reference sequences that belong to a specific genome build. Explain