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    Pfkl phosphofructokinase, liver type [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25741, updated on 27-Nov-2024

    Summary

    Official Symbol
    Pfklprovided by RGD
    Official Full Name
    phosphofructokinase, liver typeprovided by RGD
    Primary source
    RGD:3311
    See related
    EnsemblRapid:ENSRNOG00000001214 AllianceGenome:RGD:3311
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    PFK-L; ATP-PFK
    Summary
    Enables several functions, including 6-phosphofructokinase activity; anion binding activity; and identical protein binding activity. Involved in fructose 1,6-bisphosphate metabolic process; fructose 6-phosphate metabolic process; and glycolytic process. Predicted to be located in cytosol. Predicted to be part of 6-phosphofructokinase complex. Predicted to be active in membrane. Orthologous to human PFKL (phosphofructokinase, liver type). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 188.6), Kidney (RPKM 158.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Pfkl in Genome Data Viewer
    Location:
    20p12
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (10663907..10685967)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (10664285..10686324)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (11393860..11415889)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene DNA methyltransferase 3 like Neighboring gene autoimmune regulator Neighboring gene cilia and flagella associated protein 410 Neighboring gene transient receptor potential cation channel, subfamily M, member 2 Neighboring gene Z6 small nucleolar RNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 6-phosphofructokinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to 6-phosphofructokinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables 6-phosphofructokinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables 6-phosphofructokinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables fructose binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables fructose-2,6-bisphosphate 2-phosphatase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables fructose-6-phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables fructose-6-phosphate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables fructose-6-phosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables monosaccharide binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in canonical glycolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in fructose 1,6-bisphosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in fructose 1,6-bisphosphate metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in fructose 1,6-bisphosphate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fructose 6-phosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in fructose 6-phosphate metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within fructose 6-phosphate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fructose 6-phosphate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glycolytic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in glycolytic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within glycolytic process through fructose-6-phosphate ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glycolytic process through fructose-6-phosphate ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to glucose ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to glucose ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to glucose ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of 6-phosphofructokinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of 6-phosphofructokinase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    ATP-dependent 6-phosphofructokinase, liver type
    Names
    6-phosphofructokinase type B
    6-phosphofructokinase, liver type
    PFK-B
    phosphofructo-1-kinase isozyme B
    phosphofructokinase 1
    phosphofructokinase, liver, B-type
    phosphohexokinase
    NP_037322.1
    XP_008771020.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013190.4NP_037322.1  ATP-dependent 6-phosphofructokinase, liver type

      See identical proteins and their annotated locations for NP_037322.1

      Status: PROVISIONAL

      Source sequence(s)
      X58865
      UniProtKB/Swiss-Prot
      P30835
      UniProtKB/TrEMBL
      Q6P783
      Related
      ENSRNOP00000100786.1, ENSRNOT00000147989.1
      Conserved Domains (1) summary
      cd00764
      Location:13773
      Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      10663907..10685967
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008772798.4XP_008771020.1  ATP-dependent 6-phosphofructokinase, liver type isoform X1

      UniProtKB/TrEMBL
      Q6P783
      Related
      ENSRNOP00000001625.4, ENSRNOT00000001625.7
      Conserved Domains (2) summary
      cd00764
      Location:13796
      Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
      TIGR02478
      Location:16778
      6PF1K_euk; 6-phosphofructokinase, eukaryotic type