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    NEW1 New1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855875, updated on 9-Dec-2024

    Summary

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    Official Symbol
    NEW1
    Official Full Name
    New1p
    Primary source
    SGD:S000006147
    Locus tag
    YPL226W
    See related
    AllianceGenome:SGD:S000006147; FungiDB:YPL226W; VEuPathDB:YPL226W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ribosome binding activity and translation termination factor activity. Involved in regulation of translational termination and ribosomal small subunit biogenesis. Located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See NEW1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (121767..125357)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene polynucleotide 5'-phosphatase Neighboring gene dolichyl-phosphate beta-glucosyltransferase Neighboring gene ribosome-associated Tef1p biogenesis chaperone CHP1 Neighboring gene Mmt2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The ABCF ATPase New1 resolves translation termination defects associated with specific tRNAArg and tRNALys isoacceptors in the P site. Turnbull K, et al. Nucleic Acids Res, 2024 Oct 28. PMID 39217469, Free PMC Article
    2. Yeast prion protein New1 can break Sup35 amyloid fibrils into fragments in an ATP-dependent manner. Inoue Y, et al. Genes Cells, 2011 May. PMID 21453424
    3. Molecular basis of a yeast prion species barrier. Santoso A, et al. Cell, 2000 Jan 21. PMID 10660050
    4. The ABCF gene family facilitates disaggregation during animal development. Skuodas S, et al. Mol Biol Cell, 2020 Jun 15. PMID 32320318, Free PMC Article
    5. Multiple Gln/Asn-rich prion domains confer susceptibility to induction of the yeast [PSI(+)] prion. Osherovich LZ, et al. Cell, 2001 Jul 27. PMID 11511346

    See all (108) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The results suggest that New1 is a translation factor that fine-tunes the efficiency of translation termination or ribosome recycling.
      Title: A role for the Saccharomyces cerevisiae ABCF protein New1 in translation termination/recycling.
    2. Data show that full-length New1 broke the Sup35NM amyloid fibrils in an ATP-dependent manner.
      Title: Yeast prion protein New1 can break Sup35 amyloid fibrils into fragments in an ATP-dependent manner.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding HDA PubMed 
    enables ribosome binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables translation termination factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in poly(A)+ mRNA export from nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of translational termination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal small subunit biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translational termination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    New1p
    NP_015098.1
    • Translation termination and ribosome biogenesis factor; ATP binding cassette protein that cosediments with polysomes and is required for biogenesis of the small ribosomal subunit; Asn/Gln-rich rich region supports [NU+] prion formation and susceptibility to [PSI+] prion induction

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      121767..125357
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184040.1 → NP_015098.1  TPA: New1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015098.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3E4, Q05402, Q08972, Q7LHP2
      UniProtKB/TrEMBL
      G2WNV9, N1NWL9
      Conserved Domains (2) summary
      COG0488
      Location:572 → 1122
      Uup; ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]
      sd00044
      Location:183 → 214
      HEAT; HEAT repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08972.1

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