Aplp2 amyloid beta precursor like protein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Aplp2provided by RGD
Official Full Name: amyloid beta precursor like protein 2provided by RGD
Primary source: RGD:2128
See related: EnsemblRapid:ENSRNOG00000047179 AllianceGenome:RGD:2128
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Apph; CDEBP; APLP-2; WALPLP2
Summary: Predicted to enable identical protein binding activity and serine-type endopeptidase inhibitor activity. Predicted to be involved in axonogenesis and central nervous system development. Predicted to act upstream of or within several processes, including brain development; regulation of epidermal growth factor-activated receptor activity; and suckling behavior. Predicted to be located in nucleus. Predicted to be active in spine apparatus. Used to study Alzheimer's disease. Biomarker of neurodegenerative disease. Orthologous to human APLP2 (amyloid beta precursor like protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 1040.3), Lung (RPKM 878.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q13

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (37857407..37920487, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (29599230..29662311, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (32298526..32328821, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

alanine in APP- intracellular domain(ICD) and the proline in APLP2-ICD lie directly behind a conserved caspase cleavage site
Title: A single amino acid difference between the intracellular domains of amyloid precursor protein and amyloid-like precursor protein 2 enables induction of synaptic depression and block of long-term potentiation.
This study demonstrated that the downregulation of amyloid beta precursor in Rat Medial Temporal Lobe Cortex Following Transient Global Brain ischemia.
Title: Discrepancy in Expression of β-Secretase and Amyloid-β Protein Precursor in Alzheimer-Related Genes in the Rat Medial Temporal Lobe Cortex Following Transient Global Brain Ischemia.
Findings demonstrate that both acute and chronic Immobilization Stress lead to gene transcriptional changes of beta-actin, APP and MAPK-1. These changes may lead to cognitive deterioration, and the development of Alzheimer disease.
Title: [Acute and chronic stress induced changes in gene transcriptions related to Alzheimer's disease].
The APLP2 gene has both a GAGA sequence and a CAGA box immediately upstream of a position corresponding to the APP gene CAGA box.
Title: Presence of a "CAGA box" in the APP gene unique to amyloid plaque-forming species and absent in all APLP-1/2 genes: implications in Alzheimer's disease.
The expression of APLP2 is up-regulated in the striatum following dopaminergic denervation
Title: Identification and comparative analysis of differentially expressed proteins in rat striatum following 6-hydroxydopamine lesions of the nigrostriatal pathway: up-regulation of amyloid precursor-like protein 2 expression.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH142178 (e-PCR)
- UniSTS:231428

RH127464 (e-PCR)
- UniSTS:210774

MARC_21333-21334:1023126386:1 (e-PCR)
- UniSTS:268532

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables transition metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in axonogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in central nervous system development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cholesterol metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within extracellular matrix organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within forebrain development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intracellular copper ion homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within locomotory behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mating behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within midbrain development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuromuscular process controlling balance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of epidermal growth factor-activated receptor activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within suckling behavior	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endomembrane system	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in spine apparatus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: amyloid beta precursor like protein 2

Names: Amyloid protein precursor-like protein 2; CDEI box-binding protein; amyloid beta (A4) precursor-like protein 2; amyloid beta (A4) precursor-like protein 2-like; amyloid protein homolog; amyloid-like protein 2; sperm membrane protein (YWK-II)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012906.1 → NP_037038.1 amyloid beta precursor like protein 2 isoform 1 precursor

See identical proteins and their annotated locations for NP_037038.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) is the longer transcript and encodes the longer isoform (1).

Source sequence(s)

BP497339, CA340752, CB700594, CB795867, FM029818, FM030557, FM039816, FM041002, FM044356, FM104554, FM112636

UniProtKB/Swiss-Prot

P15943

UniProtKB/TrEMBL

A6JYG2, M0RDX2

Related

ENSRNOP00000067835.3, ENSRNOT00000070818.5

Conserved Domains (6) summary

smart00006
Location:42 → 204

A4_EXTRA; amyloid A4

pfam00014
Location:311 → 363

Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

pfam02177
Location:49 → 147

APP_N; Amyloid A4 N-terminal heparin-binding

pfam10515
Location:711 → 761

APP_amyloid; beta-amyloid precursor protein C-terminus

pfam12924
Location:149 → 204

APP_Cu_bd; Copper-binding of amyloid precursor, CuBD

pfam12925
Location:367 → 549

APP_E2; E2 domain of amyloid precursor protein
NM_022520.1 → NP_071965.1 amyloid beta precursor like protein 2 isoform 2 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an in-frame coding exon and encodes a shorter isoform (2), compared to variant 1.

Source sequence(s)

BP497339, CA340752, CB700594, CB795867, FM029818, FM030557, FM039816, FM041002, FM044356, FM104554, FM112636

UniProtKB/Swiss-Prot

P15943

Related

ENSRNOP00000067077.4, ENSRNOT00000074457.5

Conserved Domains (6) summary

smart00006
Location:42 → 204

A4_EXTRA; amyloid A4

pfam00014
Location:311 → 363

Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

pfam02177
Location:49 → 147

APP_N; Amyloid A4 N-terminal heparin-binding

pfam10515
Location:699 → 749

APP_amyloid; beta-amyloid precursor protein C-terminus

pfam12924
Location:149 → 204

APP_Cu_bd; Copper-binding of amyloid precursor, CuBD

pfam12925
Location:367 → 549

APP_E2; E2 domain of amyloid precursor protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

37857407..37920487 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039082084.1 → XP_038938012.1 amyloid beta precursor like protein 2 isoform X2

UniProtKB/Swiss-Prot

P15943

UniProtKB/TrEMBL

A6JYG1

Conserved Domains (3) summary

smart00006
Location:42 → 204

A4_EXTRA; amyloid A4

pfam12925
Location:311 → 493

APP_E2; E2 domain of amyloid precursor protein

cd21709
Location:614 → 694

JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins
XM_039082083.1 → XP_038938011.1 amyloid beta precursor like protein 2 isoform X1

UniProtKB/Swiss-Prot

P15943

UniProtKB/TrEMBL

A0A8I5ZSU5

Related

ENSRNOP00000081588.1, ENSRNOT00000097481.2

Conserved Domains (3) summary

smart00006
Location:42 → 204

A4_EXTRA; amyloid A4

pfam12925
Location:311 → 493

APP_E2; E2 domain of amyloid precursor protein

cd21709
Location:626 → 706

JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins